EPH Receptor B1 Protein (EPHB1) (His tag)

N° du produit ABIN7195545

Détail du produit

Antigène: EPH Receptor B1 (EPHB1)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette EPH Receptor B1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse EphB1/EPHT2 Protein (His Tag)(Active)

Séquence: Met 1-Leu 539

Attributs du produit: A DNA sequence encoding the mouse EPHB1 (Q8CBF3-1) extracellular domain (Met 1-Leu 539) was expressed, with a polyhistidine tag at the C-terminus.

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Immobilized mouse EPHB1-His at 10 μg/ml (100 μl/well) can bind mouse EFNB1-Fc, The EC50 of mouse EFNB1-Fc is 0.04-0.08 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: EPH Receptor B1 (EPHB1)

Autre désignation: EphB1/EPHT2 (EPHB1 Produits)

Synonymes: ELK Protein, EPHT2 Protein, Hek6 Protein, NET Protein, ephb1-a Protein, xek Protein, Xek Protein, MGC89790 Protein, EPHB1 Protein, CEK6 Protein, EK6 Protein, 9330129L11 Protein, AW488255 Protein, C130099E04Rik Protein, Cek6 Protein, ENSMUSG00000074119 Protein, Elk Protein, Elkh Protein, Net Protein, Ephb2 Protein, Erk Protein, elk Protein, EPH receptor B1 Protein, EPH receptor B1 S homeolog Protein, ephrin type-B receptor 1 Protein, Eph receptor B1 Protein, EPHB1 Protein, ephb1.S Protein, ephb1 Protein, LOC100467687 Protein, Ephb1 Protein

Sujet:

Background: Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Synonym: 9330129L11,AW488255,C130099E04Rik,Cek6,Elk,Elkh,ENSMUSG00000074119,Hek6,Net

Poids moléculaire: 59.6 kDa

Pathways: Signalisation RTK