eIF4EBP1 Protéine

N° du produit ABIN7938835

Protéine Recombinant eIF4EBP1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour eIF4EBP1 Protéine (ABIN7938835)

Antigène: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant EIF4EBP1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant EIF4EBP1 protein is supplied in 25 mM Tris pH 7.4, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Autre désignation: EIF4EBP1

Sujet:

Protein Background: EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1 ) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Short Description: Recombinant EIF4EBP1 protein was expressed in E.coli as the full length protein (accession number NP_004086.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 14.51 kDa.

Aliases: Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Regulation of Cell Size, BCR Signaling