Neuregulin 1 Protein (NRG1) (AA 2-246)

N° du produit ABIN8057045

Protéine Recombinant Neuregulin 1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Neuregulin 1 Protein (NRG1) (AA 2-246) (ABIN8057045)

Antigène: Neuregulin 1 (NRG1)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 85 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 2-246

Fonction: Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 2-246)

Séquence: Ser2-Lys246

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 0.01 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Neuregulin 1 (NRG1)

Autre désignation: Pro-Neuregulin-1

Sujet: EGF,GGF,HGL,HRG1-beta 1,HRGA,NDF,NRG1,NRG1-beta 1,Neuregulin-1 beta 1,Pro-neuregulin-1,SMDF,Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, stimulating Schwann cell proliferation, implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Poids moléculaire:

Calculated MW: 26.9 kDa

Observed MW: 34 kDa

ID gène: 3084

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation