Neuregulin 1 Protein (NRG1) (AA 176-246)

N° du produit ABIN8057047

Cette protéine Recombinant Neuregulin 1 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Neuregulin 1 Protein (NRG1) (AA 176-246) (ABIN8057047)

Antigène: Neuregulin 1 (NRG1)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 176-246

Fonction: Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 176-246)

Séquence: Thr176-Lys246

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Neuregulin 1 (NRG1)

Autre désignation: Pro-Neuregulin-1

Sujet: EGF,GGF,HGL,HRG1-beta 1,HRGA,NDF,NRG1,NRG1-beta 1,Neuregulin-1 beta 1,Pro-neuregulin-1,SMDF,neuregulin-1 (heregulin-1,NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Poids moléculaire:

Calculated MW: 8.2 kDa

Observed MW: 7 kDa

ID gène: 3084

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation