Caspase 1 Protein (CASP1)

N° du produit ABIN925024

Protéine Recombinant Caspase 1 exprimée dans Bacteria.

Aperçu rapide pour Caspase 1 Protein (CASP1) (ABIN925024)

Antigène: Caspase 1 (CASP1)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Bacteria

Détail du produit

Attributs du produit: ~8000 units/mg. One unit cleaves 1 nmol of the caspase substrate YVAD-pNA per hour at 37°C in a reaction solution containing 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10 mM DTT.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with PBS to 1 unit/µl.

Stock: -80 °C

Détail du antigène

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1

Sujet: Caspase-1 (also known as ICE, Interleulin-1- Converting Enzyme) is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.

Poids moléculaire: 45 kDa

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome