Epiregulin Protein (EREG)
Aperçu rapide pour Epiregulin Protein (EREG) (ABIN935331)
Antigène
Voir toutes Epiregulin (EREG) ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Séquence
- MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
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Attributs du produit
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Purified recombinant Human Epiregulin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is ? 2.0 ng/mL, corresponding to a specific activity of ? 5 x 10^5units/mg. -
niveau d'endotoxine
- < 0.1 ng per µg (1 EU/µg).
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Epiregulin (EREG) (AA 56-101) protein (Fc Tag)
EREG Origine: Souris Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epiregulin (EREG) (AA 63-108) protein (Fc Tag)EREG Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Epiregulin (EREG) (AA 60-108) protein (His-IF2DI Tag)EREG Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Epiregulin (EREG) (AA 1-169) protein (GST tag)EREG Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- RT/-20 °C
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- Epiregulin (EREG)
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Autre désignation
- Epiregulin
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Sujet
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Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Alternative Names: EREG protein -
Poids moléculaire
- 5.6 kDa
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Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
Antigène
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