HBEGF Protéine

N° du produit ABIN935466

Cette protéine Recombinant HBEGF est exprimée dans Insect cells (Sf9).

Aperçu rapide pour HBEGF Protéine (ABIN935466)

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Type de proteíne: Recombinant

Origine: Humain

Source: Insect cells (Sf9)

Détail du produit

Attributs du produit: Purified recombinant Human HB-EGF protein
Expression System: Spodoptera frugiperda

niveau d'endotoxine: < 1.0 EU per 1 µg of the protein by the LAL method.

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: RT/-20 °C

Détail du antigène

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Autre désignation: HB-EGF

Sujet: HBEGF was originally purified based on its heparinbinding property and mitogenic activity on BALB3T3 fibroblasts from the conditioned medium of the human U937 histiocytic lymphoma cell line. The natural protein has an apparent molecular mass of 19 23 kDa and exists in multiple forms as a result of heterogenous Oglycosylation and/or Nterminal truncation. In addition to fibroblasts, HB EGF is also a potent mitogen for keratinocytes and smooth muscle cells but not for capillary endothelial cells. HBEGF is produced in monocytes and macrophages. In addition, transcription of HBEGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells (SMC), suggesting that HB EGF may have an important role in the pathogenesis of atherosclerosis.
Alternative Names: Heparin Binding Epidermal Growth Factor protein, HB EGF protein

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway