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SARS-CoV-2 Spike S1 Protéines

(SARS-CoV-2 Spike S1)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

90 Résultats

Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. SDS, Func
Pubmed 9 références
N° du produit ABIN6952427
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274393
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
Pubmed 5 références
N° du produit ABIN6952456
 
Origine: SARS Coronavirus (SARS-CoV) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275552
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274394
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274391
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7273920
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7273902
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274459
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274404
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274778
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275137
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274405
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
N° du produit ABIN6952462
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE.
> 90 % as determined by SEC-MALS.
ELISA, SDS
Pubmed 5 références
N° du produit ABIN6952628
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. ELISA, SDS
Pubmed 1 reference
N° du produit ABIN6952624
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. ELISA, SDS
Pubmed 1 reference
N° du produit ABIN6952632
 
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 1 reference
N° du produit ABIN7013274
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. ELISA, SDS
N° du produit ABIN6953175
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. ELISA, SDS
N° du produit ABIN6953173
 
  • Type Protein
    • Protein
  • Application
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Functional Studies (Func)
    • Lateral Flow (LF)
    • Control (Ct)
    • Enzyme Immunoassay (EIA)
    • Immunogen (Imm)
    • Positive Control (PC)
  • Réactivité
    • SARS Coronavirus-2 (SARS-CoV-2)
    • SARS Coronavirus (SARS-CoV)
    • SARS CoV-2 Beta
    • SARS CoV-2 Omicron
    • SARS CoV-2 Delta
    • Coronavirus (CoV)
    • SARS CoV-2 Alpha
    • SARS CoV-2 Gamma
    • SARS CoV-2 Kappa
  • Cité dans publications
  • Images disponible
  • Sans conservateur uniquement
  • Carrier free only
  • Hote
    • HEK-293 Cells
    • Insect Cells
    • Escherichia coli (E. coli)
    • Baculovirus infected Insect Cells
    • CHO Cells
    • Human Cells
    • Tobacco (Nicotiana benthamiana)
  • Epitope
    • RBD
    • AA 16-685
    • D614G
    • N-Term
    • B.1.351 - beta
    • AA 1-674
    • AA 319-541
    • B.1.1.529 - Omicron
    • B.1.617.2 - delta
    • N501Y
    • BA.4 - Omicron
    • BA.5 - Omicron
    • Extracellular Domain
    • P.1 - gamma
    • AA 1-305
    • AA 1-681
    • AA 1-685
    • AA 14-683
    • AA 14-685
    • AA 315-535
    • AA 330-530
    • Asp614Gly
    • B.1.1.7 - alpha
    • B.1.617.1 - kappa
    • B.1.640
    • BA.2 - Omicron
    • BA.2.12.1 - Omicron
    • BA.2.75 - Omicron
    • C-Term
    • C.37 - Lambda
    • Deltacron
    • E484K
    • G476S
    • K417N
    • NTD
    • V367F
    • V483A
    • W436R
  • Conjugué
    • His tag
    • Fc Tag
    • mFc Tag
    • His tag,AVI tag,Biotin
    • His-Avi Tag
    • Fc-Avi Tag
    • His-Avi Tag,Biotin
    • Fc-Avi Tag,Biotin
    • Inconjugué
    • Biotin
    • Biotin,His-Avi Tag
    • Fc-His Tag
    • GST tag,His tag
    • His tag,Biotin
    • His tag,Fc Tag
    • His tag,SEKDEL Tag
    • His-DYKDDDDK Tag
    • sFc-Tag
  • Type Proteine
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Activité biologique
    • Biologically Active
    • Biologically Inactive
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • ProSci
    • RayBiotech

Dernières publications pour nos SARS-CoV-2 Spike S1 Protéines

Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." dans: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

Fan, Parr, Kang, Gupta: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." dans: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).

Kaneko, Satta, Komuro, Muthukrishnan, Kakarla, Guo, An, Elahi, Kornblum, Liebeskind, Hsiai, Hinman: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." dans: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).

Sasisekharan, Pentakota, Jayaraman, Tharakaraman, Wogan, Narayanasami: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." dans: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Narang, James, Balmer, Wilson: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." dans: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).

Fiedler, Piziorska, Denninger, Morgunov, Ilsley, Malik, Schneider, Devenish, Meisl, Kosmoliaptsis, Aguzzi, Fiegler, Knowles: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." dans: ACS infectious diseases, (2021) (PubMed).

Lucas, Klein, Sundaram, Liu, Wong, Silva, Mao, Oh, Mohanty, Huang, Tokuyama, Lu, Venkataraman, Park, Israelow, Vogels, Muenker, Chang, Casanovas-Massana, Moore, Zell, Fournier, Wyllie, Campbell, Lee et al.: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." dans: Nature medicine, (2021) (PubMed).

Song, Bartley, Chow, Ngo, Jiang, Zamecnik, Dandekar, Loudermilk, Dai, Liu, Sunshine, Liu, Wu, Hawes, Alvarenga, Huynh, McAlpine, Rahman, Geng, Chiarella, Goldman-Israelow, Vogels, Grubaugh et al.: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." dans: Cell reports. Medicine, pp. 100288, (2021) (PubMed).

Guo, Huang, Zhang, Yao, Zhou, Shen, Shen, Li, Li, Zhang, Chen, Chen, Wu, Fu, Zeng, Feng, Pi, Wang, Zhou, Lu, Li, Fang, Lu, Hu, Wang, Zhang, Gao, Adrian, Wang, Yu, Peng, Gabibov, Min, Wang, Huang et al.: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." dans: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).

Pseudonymes pour SARS-CoV-2 Spike S1 Protéines

Surface Glycoprotein (S) Protéines
E2 Protéines
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