SARS-CoV-2 Spike S1 Protéines
(SARS-CoV-2 Spike S1)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
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90 Résultats
Origine: Coronavirus (CoV)
Hôte: HEK-293 Cells
Recombinant
Greater than 90 % as determined by SDS-PAGE.
WB, ELISA
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: CHO Cells
Recombinant
>95 % as determined by SDS-PAGE and HPLC
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
>95 %
ELISA, LF, Ct
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 95 %
Inactive
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 90 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 95 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 90 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 85 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 90 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 85 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: Baculovirus infected Insect Cells
Recombinant
> 90 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 90 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
>85 %
ELISA, LF
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: Cellules d'insectes
Recombinant
>85 %
ELISA, LF
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
>95 %
Ct
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: Cellules d'insectes
Recombinant
> 85 % by SDS-PAGE
WB, ELISA
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: Cellules d'insectes
Recombinant
WB, EIA
Origine: SARS Coronavirus-2 (SARS-CoV-2)
Hôte: HEK-293 Cells
Recombinant
> 95 %
ELISA
Active
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
Hôte: HEK-293 Cells
Recombinant
> 95% as determined by SDS-PAGE.
SDS
1 image
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Delta
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
1 reference
Dernières publications pour nos SARS-CoV-2 Spike S1 Protéines
: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." dans: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." dans: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).
: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." dans: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).
: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).
: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." dans: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).
: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." dans: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).
: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." dans: ACS infectious diseases, (2021) (PubMed).
: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." dans: Nature medicine, (2021) (PubMed).
: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." dans: Cell reports. Medicine, pp. 100288, (2021) (PubMed).
: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." dans: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).
Pseudonymes pour SARS-CoV-2 Spike S1 Protéines
Surface Glycoprotein (S) ProtéinesE2 Protéines
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