Souris anti-Humain Immunoglobulin kappa Chain Complex (Igk) (Light Chain) Anticorps

N° du produit ABIN7879474

Aperçu rapide pour Souris anti-Humain Immunoglobulin kappa Chain Complex (Igk) (Light Chain) Anticorps (ABIN7879474)

Antigène: Igk (Immunoglobulin kappa Chain Complex (Igk))

Clonalité: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM508

Isotype: IgG1, kappa

Détail du produit

Épitope: Light Chain

Reactivité: Humain

Hôte: Souris

Fonction: Kappa Light Chain Antibody

Purification: Protein G affinity chromatography

Immunogène: Human B-lymphoma cells were used as the immunogen for this Kappa Light Chain antibody.

Information d'application

Indications d'application: The optimal dilution of the Kappa Light Chain antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Kappa Light Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Igk (Immunoglobulin kappa Chain Complex (Igk))

Autre désignation: Kappa

Sujet: This mAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

UniProt: P01601