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SF3A1 Produits

(Splicing Factor 3a, Subunit 1 (SF3A1))

Catégories

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Catégories SF3A1 en vedette

SF3A1 Anticorps

High quality antibodies with extensive validation data.

SF3A1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SF3A1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (5)
N° du produit ABIN1491272
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, IHC (p)
Validations
  • (3)
N° du produit ABIN5587791
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC, IF
Validations
  • (1)
  • (3)
N° du produit ABIN2778958
Quantité 100 μL
Fiche technique Fiche technique

SF3A1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6232341
Quantité 96 tests
Fiche technique Fiche technique

SF3A1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319703
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319702
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3095359
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SF3A1

Han, Shen, Zhang, Jayabal, Che, Zhang, Yu, Fei: "Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression." dans: Oncotarget, Vol. 8, Issue 14, pp. 22490-22500, (2017) (PubMed).

Han, Park, Ching, Panneerselvam, Wang, Shen, Zhang, Li, Che, Garmire, Fei: "Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development." dans: Oncogene, Vol. 36, Issue 38, pp. 5382-5391, (2017) (PubMed).

Jackson, Du, Janesko-Feldman, Vagni, Dezfulian, Poloyac, Jackson, Clark, Kochanek: "The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 35, Issue 4, pp. 655-66, (2015) (PubMed).

Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: "The core spliceosome as target and effector of non-canonical ATM signalling." dans: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).

Joo, Correia, Li, Lopez, Baker, Sugrue: "Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells." dans: Investigative ophthalmology & visual science, Vol. 54, Issue 1, pp. 697-707, (2013) (PubMed).

Yoshimoto, Kataoka, Okawa, Ohno: "Isolation and characterization of post-splicing lariat-intron complexes." dans: Nucleic acids research, Vol. 37, Issue 3, pp. 891-902, (2009) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).

Nesic, Krämer: "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation." dans: Molecular and cellular biology, Vol. 21, Issue 19, pp. 6406-17, (2001) (PubMed).

Das, Zhou, Reed: "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E." dans: Molecular cell, Vol. 5, Issue 5, pp. 779-87, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à SF3A1

CG16941 gene product from transcript CG16941-RA (CG16941), SWAP/Surp domain-containing protein (sf3a1), splicing factor 3a, subunit 1 (sf3a1), splicing factor 3a, subunit 1 (spl1), splicing factor 3a, subunit 1 (Sf3a1), splicing factor 3a subunit 1 (SF3A1), 1200014H24Rik, 5930416L09Rik, AI159724, DDBDRAFT_0168938, DDBDRAFT_0233180, DDB_0168938, DDB_0233180, Dmel\\CG16941, PRP21, PRPF21, SAP114, SF3a1, SF3a120, SF3A120, si:dz150f13.2, wu:fc38e01, wu:fc50a11, wu:fj37c05, zgc:65786

Protein level used designations for SF3A1

  • CG16941-PA
  • splicing factor 3a, subunit 1
  • splicing factor 3A subunit 1
  • ubiquitin domain-containing protein
  • Splicing factor 3 subunit 1
  • SF3a120
  • splicing factor 3 subunit 1
  • splicing factor 3a, subunit 1, 120kDa
  • SAP 114
  • pre-mRNA processing 21
  • pre-mRNA splicing factor SF3a (120 kDa subunit)
  • spliceosome-associated protein 114
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