Tel:: +49 (0)241 95 163 153
Fax:: +49 (0)241 95 163 155
E-Mail:: orders@anticorps-enligne.fr

Pour une meilleure utilisation, nous vous conseillons d’activer Javascript dans votre navigateur.

SMURF2 Protéines

(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Filtrer les résultats:

Tous les filtres

Voulez-vous essayer notre recherche AI ?

Afficher les filtres

8 Résultats

SMURF2 Protein (AA 1-748) (His tag)

custom-made SMURF2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant SMURF2 Protein, UniprotID Q9HAU4

3 images

N° du produit ABIN7555579

Détails

SMURF2 Protein (AA 1-748) (His tag)

custom-made SMURF2 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Smurf2 Protein, UniprotID A2A5Z6

3 images

N° du produit ABIN7561867

Détails

SMURF2 Protein (His tag)

SMURF2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant SDS, ELISA, WB

N° du produit ABIN7579604

Détails

SMURF2 Protein (AA 1-748) (Strep Tag)

custom-made SMURF2 Origine: Souris Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB

N° du produit ABIN3130681

Détails

SMURF2 Protein (AA 1-748) (Strep Tag)

custom-made SMURF2 Origine: Humain Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB

N° du produit ABIN3095583