SMURF2 Produits
(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
Catégories
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
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Catégories SMURF2 en vedette
SMURF2 Anticorps
High quality antibodies with extensive validation data.
SMURF2 Kits ELISA
Reliable ELISA kits for a wide range of species.
SMURF2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SMURF2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (4)
N° du produit
ABIN753178
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, IF, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN388831
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (4)
N° du produit
ABIN7101462
Quantité
20 μL
Fiche technique
Fiche technique
SMURF2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970246
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959517
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1131328
Quantité
96 tests
Fiche technique
Fiche technique
SMURF2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3095583
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3130681
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN5711831
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SMURF2
: "TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2." dans: Cell death and differentiation, (2019) (PubMed).: "Human trabecular meshwork cells express BMP antagonist mRNAs and proteins." dans: Experimental eye research, Vol. 147, pp. 156-60, (2016) (PubMed).
: "The proteasome inhibitor, MG132, attenuates diabetic nephropathy by inhibiting SnoN degradation in vivo and in vitro." dans: BioMed research international, Vol. 2014, pp. 684765, (2015) (PubMed).
: "Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-? inhibition of mesenchymal stem cell osteogenic differentiation." dans: PLoS ONE, Vol. 7, Issue 3, pp. e31717, (2012) (PubMed).
: "TRB3 interacts with SMAD3 promoting tumor cell migration and invasion." dans: Journal of cell science, Vol. 124, Issue Pt 19, pp. 3235-46, (2011) (PubMed).
: "The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein." dans: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40354-64, (2011) (PubMed).
: "The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." dans: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 35259-68, (2007) (PubMed).
: "Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." dans: The EMBO journal, Vol. 26, Issue 5, pp. 1410-22, (2007) (PubMed).
: "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 3, pp. 974-9, (2001) (PubMed).
: "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation." dans: Molecular cell, Vol. 6, Issue 6, pp. 1365-75, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à SMURF2
SMAD specific E3 ubiquitin protein ligase 2 (SMURF2), SMAD specific E3 ubiquitin protein ligase 2 (smurf2), SMAD specific E3 ubiquitin protein ligase 2 (Smurf2), SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S), 2810411E22Rik, AI558114, AI649275, RGD1310067, SMURF2, wu:fb82a11, wu:fc41c02Protein level used designations for SMURF2
- SMAD specific E3 ubiquitin protein ligase 2
- E3 ubiquitin-protein ligase SMURF2-like
- e3 ubiquitin-protein ligase SMURF2-like
- E3 ubiquitin ligase SMURF2
- E3 ubiquitin-protein ligase SMURF2
- SMAD ubiquitination regulatory factor 2
- SMAD-specific E3 ubiquitin-protein ligase 2
- hSMURF2
- E3 ubiquitin ligase Smurf2
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