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SNCA Protéines

(Synuclein, alpha (SNCA))

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].

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SNCA Protein (A53T)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

Primary rat hippocampal neurons show lewy body inclusion formation when treated with A53T mutant Alpha Synuclein Protein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305) (B) but not when treated with a media control (A).

Evaluation of a-syn toxicity on primary mouse cortical neurons.

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in alpha synuclein fibrils.

Evaluation of a-syn toxicity on primary mouse cortical neurons.

6 images

N° du produit ABIN6952303

SNCA Protein (full length)

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Type 1 Mouse Recombinant Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary rat hippocampal neurons show lewy body inclusion formation and loss of cells when treated with Type 1 mouse Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) at 4 μg/mL (D-F) on DVI2, but not when treated with a control (A-C).

C57/BL6 mice were injected with sonicated recombinant mouse alpha synuclein monomers or fibrils at 8 weeks of age.

C57/BL6 mice were injected with 5 μg sonicated mouse recombinant alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) at 8 weeks of age.

Immunohistochemistry analysis of rat brain injected with Type 1 mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary mouse hippocampal neurons treated with 100 nM sonicated mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) (A).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5651245, ABIN5651246 and ABIN5651247).

9 images

N° du produit ABIN5651245

SNCA Protein (full length)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >95% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Active Human Recombinant Alpha Synuclein Protein Aggregate .

Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) (Catalog No.

Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 µg/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 µg/ml (A-C).

Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (A-C).

ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165) were taken up, transported into the soma, and induced alpha synuclein aggregation in mouse neurocortical primary cells.

Confocal imaging shows NeuN+ (mature) primary cortical neurons filled with ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

Immunohistochemistry analysis of rat brain injected with Type 1 human alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

10 images

N° du produit ABIN5065829

SNCA Protein (AA 1-140) (His tag)

custom-made SNCA Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

3 images

N° du produit ABIN7544253

SNCA Protein (AA 1-140) (His tag)

custom-made SNCA Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

3 images

N° du produit ABIN7562469

SNCA Protéine

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE

Western Blotting (WB) image for Synuclein, alpha (SNCA) protein (ABIN7320688)

1 image

N° du produit ABIN7320688

SNCA Protein (AA 1-140) (His tag)

SNCA Origine: Rat Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His tag) (ABIN7125301)

1 image

N° du produit ABIN7125301

SNCA Protein (AA 1-140) (His-IF2DI Tag)

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His-IF2DI Tag) (ABIN7125300)

1 image

N° du produit ABIN7125300

SNCA Protein (active)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % pure SDS

Figure annotation denotes ug of protein loaded and % gel used.

1 image

N° du produit ABIN934871

SNCA Protein (AA 31-140) (GST tag)

SNCA Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA

Image no. 1 for Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag) (ABIN1320776)

1 image

N° du produit ABIN1320776

SNCA Protein (AA 1-140) (GST tag)

SNCA Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA

Image no. 1 for Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag) (ABIN1320774)

1 image

N° du produit ABIN1320774

SNCA Protein (AA 1-139, partial) (GST tag)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA

SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) (AA 1-139), (partial) protein (GST tag) (ABIN1046507)

1 image

3 références

N° du produit ABIN1046507

SNCA Protein (AA 1-140) (His tag)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

N° du produit ABIN7505128

SNCA Protein (AA 1-140) (His tag)

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

N° du produit ABIN7505351

SNCA Protein (AA 1-140)

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

N° du produit ABIN4371752

SNCA Protein (AA 1-140)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

N° du produit ABIN1692153

SNCA Protéine

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 97 % as determined by reducing SDS-PAGE.

N° du produit ABIN7198176

SNCA Protein (AA 1-140, K23Q) (His tag)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 85 % as determined by SDS-PAGE. WB, ELISA

N° du produit ABIN7665674

SNCA Protein (AA 23-140) (His tag)

SNCA Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, PC, Imm

N° du produit ABIN7393487

SNCA Protein (AA 23-140) (His tag)

SNCA Origine: Rat Hôte: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, PC, Imm

N° du produit ABIN7405657

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