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TERT Produits

(Telomerase Reverse Transcriptase (TERT))
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].

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Catégories TERT en vedette

TERT Anticorps

High quality antibodies with extensive validation data.

TERT Kits ELISA

Reliable ELISA kits for a wide range of species.

TERT Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TERT recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IP, FM
Validations
  • (20)
  • (8)
N° du produit ABIN6655270
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
  • (5)
N° du produit ABIN726650
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (6)
N° du produit ABIN5542472
Quantité 0.1 mg
Fiche technique Fiche technique

TERT recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6962962
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6961943
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6973670
Quantité 96 tests
Fiche technique Fiche technique

TERT recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125334
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3095894
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3131987
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits TERT

Sarıbal, Kireçtepe Aydın, Kılıç, Shakil, Balkaya: "Maternal neglect results in reduced telomerase activity and increased oxidative load in rats." dans: Stress (Amsterdam, Netherlands), pp. 1-5, (2020) (PubMed).

Logozzi, Di Raimo, Mizzoni, Andreotti, Spada, Macchia, Fais: "Beneficial Effects of Fermented Papaya Preparation (FPP®) Supplementation on Redox Balance and Aging in a Mouse Model." dans: Antioxidants (Basel, Switzerland), Vol. 9, Issue 2, (2020) (PubMed).

Xu, Yuan, Luo, Zhao, Xiao: "Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway." dans: Oxidative medicine and cellular longevity, Vol. 2020, pp. 8291413, (2020) (PubMed).

Altamura, Martano, Licenziato, Maiolino, Borzacchiello et al.: "Telomerase Reverse Transcriptase (TERT) Expression, Telomerase Activity, and Expression of Matrix Metalloproteinases (MMP)-1/-2/-9 in Feline Oral Squamous Cell Carcinoma Cell Lines Associated With ..." dans: Frontiers in veterinary science, Vol. 7, pp. 148, (2020) (PubMed).

Fan, Li, Li, Zhang, Dou, Zhao, Cao, Deng, Zhang, Li, Suo: "Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro." dans: Aging, Vol. 11, Issue 2, pp. 573-589, (2020) (PubMed).

Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." dans: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

Pawełczyk, Grancow-Grabka, Trafalska, Szemraj, Żurner, Pawełczyk: "Telomerase level increase is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized clinical trial." dans: Progress in neuro-psychopharmacology & biological psychiatry, Vol. 83, pp. 142-148, (2019) (PubMed).

Giacalone, Miller, Workalemahu, Reutzel, Ochoa, Whitmore, Stone, Tucker, Mullins: "Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter." dans: Microvascular research, Vol. 123, pp. 50-57, (2019) (PubMed).

Hugdahl, Kalvenes, Mannelqvist, Ladstein, Akslen: "Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma." dans: British journal of cancer, Vol. 118, Issue 1, pp. 98-105, (2019) (PubMed).

Wei, Yang, Shi, Shi, Ji, Hou: "Increased expression of NAF1 contributes to malignant phenotypes of glioma cells through promoting protein synthesis and associates with poor patient survival." dans: Oncogenesis, Vol. 8, Issue 4, pp. 25, (2019) (PubMed).

Synonymes et noms alternatifs relatifs à TERT

telomerase reverse transcriptase (TERT), Telomerase Reverse Transcriptase (trt-1), telomerase reverse transcriptase (Tert), telomerase reverse transcriptase (tert), Tertp (TERT), telomerase reverse transcriptase (CMU_003490), telomerase reverse transcriptase (VDBG_04487), Telomerase catalytic subunit (GL50803_16225), telomerase reverse transcriptase L homeolog (tert.L), ATTERT, chTERT, CMM9, DKCA2, DKCB4, EST2, est2, F5E19.190, F5E19_190, hEST2, hTRT, PFBMFT1, TCS1, tcs1, telomerase, telomerase reverse transcriptase, Tert, tert, tert-A, TP2, tp2, TR, TRT, trt, xTERT

Protein level used designations for TERT

  • telomerase catalytic subunit
  • telomerase-associated protein 2
  • Telomerase Reverse Transcriptase family member (trt-1)
  • telomerase reverse transcriptase
  • hypothetical protein
  • telomerase reverse transcriptase beta
  • Telomerase catalytic subunit
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