TET1 Produits
(Tet Methylcytosine Dioxygenase 1 (TET1))
Catégories
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
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Catégories TET1 en vedette
TET1 Anticorps
High quality antibodies with extensive validation data.
TET1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TET1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN1327194
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
N° du produit
ABIN7159633
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB
Validations
- (1)
N° du produit
ABIN6244141
Quantité
400 μL
Fiche technique
Fiche technique
TET1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1322493
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
N° du produit
ABIN6700690
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TET1
: "Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs." dans: Stem cells international, Vol. 2018, pp. 6013728, (2018) (PubMed).: "TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing." dans: The EMBO journal, Vol. 35, Issue 3, pp. 335-55, (2016) (PubMed).
: "Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate." dans: The Journal of biological chemistry, Vol. 291, Issue 13, pp. 6754-71, (2016) (PubMed).
: "Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells." dans: Oncology letters, Vol. 10, Issue 3, pp. 1287-1292, (2015) (PubMed).
: "Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells." dans: Molecular medicine reports, Vol. 12, Issue 4, pp. 4837-42, (2015) (PubMed).
: "Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT)." dans: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4801-12, (2015) (PubMed).
: "TET1-mediated different transcriptional regulation in prostate cancer." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 1, pp. 203-11, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à TET1
tet methylcytosine dioxygenase 1 (TET1), tet methylcytosine dioxygenase 1 (Tet1), solute carrier family 25 member 16 (SLC25A16), 2510010B09Rik, AA517754, bA119F7.1, BB001228, CXXC6, Cxxc6, D10Ertd17e, LCX, mKIAA1676Protein level used designations for TET1
- CXXC finger 6
- CXXC zinc finger 6
- CXXC-type zinc finger protein 6
- leukemia-associated protein with a CXXC domain
- methylcytosine dioxygenase TET1
- ten-eleven translocation 1 gene protein
- ten-eleven translocation-1
- tet oncogene 1
- ten-eleven translocation 1 gene protein homolog
- tet methylcytosine dioxygenase 1
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