(Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008].
TNFRSF1A
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos TNFRSF1A Protéines
Himmler, Maurer-Fogy, Krönke, Scheurich, Pfizenmaier, Lantz, Olsson, Hauptmann, Stratowa, Adolf: "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein." dans: DNA and cell biology, Vol. 9, Issue 10, pp. 705-15, (1991) (PubMed).
Gray, Barrett, Chantry, Turner, Feldmann: "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 19, pp. 7380-4, (1990) (PubMed).
Schall, Lewis, Koller, Lee, Rice, Wong, Gatanaga, Granger, Lentz, Raab: "Molecular cloning and expression of a receptor for human tumor necrosis factor." dans: Cell, Vol. 61, Issue 2, pp. 361-70, (1990) (PubMed).
Loetscher, Pan, Lahm, Gentz, Brockhaus, Tabuchi, Lesslauer: "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor." dans: Cell, Vol. 61, Issue 2, pp. 351-9, (1990) (PubMed).
Nophar, Kemper, Brakebusch, Englemann, Zwang, Aderka, Holtmann, Wallach et al.: "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form ..." dans: The EMBO journal, Vol. 9, Issue 10, pp. 3269-78, (1990) (PubMed).