TPMT Produits
(Thiopurine S-Methyltransferase (TPMT))
Catégories
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008].
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Catégories TPMT en vedette
TPMT Anticorps
High quality antibodies with extensive validation data.
TPMT Kits ELISA
Reliable ELISA kits for a wide range of species.
TPMT Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TPMT recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7435148
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (2)
- (5)
N° du produit
ABIN563239
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Dog, Human
Application
WB, IHC, IHC (p), FACS
Validations
- (6)
N° du produit
ABIN1501480
Quantité
100 μL
Fiche technique
Fiche technique
TPMT recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970609
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6962695
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959901
Quantité
96 tests
Fiche technique
Fiche technique
TPMT recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1323441
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3074765
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3131858
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits TPMT
: "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4." dans: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15054-65, (2012) (PubMed).: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." dans: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).
: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." dans: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).
: "Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 26, pp. 9394-9, (2005) (PubMed).
: "Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein." dans: Nature, Vol. 375, Issue 6533, pp. 691-4, (1995) (PubMed).
Synonymes et noms alternatifs relatifs à TPMT
thiopurine S-methyltransferase L homeolog (tpmt.L), thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2), thiopurine S-methyltransferase TpmT (tpmT), thiopurine S-methyltransferase (MCA0794), thiopurine S-methyltransferase (Pnap_4948), thiopurine S-methyltransferase (Hhal_1383), thiopurine S-methyltransferase (TK90_1044), thiopurine S-methyltransferase (Slit_1144), thiopurine S-methyltransferase (Tint_0842), Thiopurine S-methyltransferase (Fbal_3334), thiopurine S-methyltransferase (Celly_3188), thiopurine S-methyltransferase (Weevi_1737), Thiopurine S-methyltransferase (Psefu_2696), Thiopurine S-methyltransferase (Metme_3860), thiopurine methyltransferase (Tpmt), thiopurine S-methyltransferase (TPMT), thiopurine S-methyltransferase (Tpmt), AW106912, MGC84277, NHLRC1Protein level used designations for TPMT
- thiopurine S-methyltransferase
- Thiopurine S-methyltransferase
- S-adenosyl-L-methionine:thiopurine S-methyltransferase
- thiopurine methyltransferase
- NHL repeat containing 1
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