TYMS Produits
(Thymidylate Synthetase (TYMS))
Catégories
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
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Catégories TYMS en vedette
TYMS Anticorps
High quality antibodies with extensive validation data.
TYMS Kits ELISA
Reliable ELISA kits for a wide range of species.
TYMS Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TYMS recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
N° du produit
ABIN7436399
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (8)
N° du produit
ABIN2855587
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, FACS, IHC, ISt, RIA, StM
Validations
- (7)
N° du produit
ABIN6940822
Quantité
100 μg
Fiche technique
Fiche technique
TYMS recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959948
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1161751
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1161752
Quantité
96 tests
Fiche technique
Fiche technique
TYMS recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN666924
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1324257
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1324259
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TYMS
: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." dans: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." dans: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).
: "Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment." dans: Annals of surgical oncology, Vol. 18, Issue 9, pp. 2442-52, (2012) (PubMed).
: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." dans: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).
: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." dans: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).
: "Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate." dans: Journal of the National Cancer Institute, Vol. 96, Issue 2, pp. 134-44, (2004) (PubMed).
: "Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines." dans: Molecular cancer therapeutics, Vol. 2, Issue 2, pp. 151-63, (2003) (PubMed).
: "Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 12, pp. 1563-74, (1999) (PubMed).
: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." dans: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à TYMS
thymidylate synthetase (TYMS), thymidylate synthetase (thyA), contains intron in T4 phage (td), thymidylate synthetase (td), ThyE (thyE), thymidylate synthase (DDA3937_RS04960), thymidylate synthetase L homeolog (tyms.L), thymidylate synthase (XBJ1_RS15770), thymidylate synthase (EAMY_RS20680), thymidylate synthase (Tyms), thymidylate synthetase (Tyms), ECK2823, FN1, HST422, JW2795, TMS, ts, Ts, TSProtein level used designations for TYMS
- fibronectin 1
- thymidylate synthase
- thymidylate synthetase
- thymidylate synthase-like
- Tsase
- TSase
- TS
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