TYROBP Produits
(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
Catégories
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
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Catégories TYROBP en vedette
TYROBP Anticorps
High quality antibodies with extensive validation data.
TYROBP Kits ELISA
Reliable ELISA kits for a wide range of species.
TYROBP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TYROBP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN653819
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
IHC
Validations
- (2)
N° du produit
ABIN7261337
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
N° du produit
ABIN6265826
Quantité
100 μL
Fiche technique
Fiche technique
TYROBP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6971010
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960320
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN5593698
Quantité
96 tests
Fiche technique
Fiche technique
TYROBP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1324265
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1324267
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3110231
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits TYROBP
: "Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome." dans: Journal of neuroinflammation, Vol. 16, Issue 1, pp. 63, (2019) (PubMed).: "The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival." dans: The Journal of biological chemistry, Vol. 294, Issue 31, pp. 11910-11919, (2019) (PubMed).
: "CD33 modulates TREM2: convergence of Alzheimer loci." dans: Nature neuroscience, Vol. 18, Issue 11, pp. 1556-8, (2016) (PubMed).
: "Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis." dans: Neuropathology and applied neurobiology, Vol. 41, Issue 7, pp. 952-63, (2015) (PubMed).
: "DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells." dans: Journal of leukocyte biology, Vol. 94, Issue 2, pp. 301-13, (2013) (PubMed).
: "The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function." dans: Immunology today, Vol. 21, Issue 12, pp. 611-4, (2001) (PubMed).
: "Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts." dans: Nature genetics, Vol. 25, Issue 3, pp. 357-61, (2000) (PubMed).
: "Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice." dans: Immunity, Vol. 13, Issue 3, pp. 355-64, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à TYROBP
TYRO protein tyrosine kinase binding protein (TYROBP), TYRO protein tyrosine kinase binding protein (tyrobp), Tyro protein tyrosine kinase binding protein (Tyrobp), TYRO protein tyrosine kinase binding protein (Tyrobp), DAP12, dap12, Karap, KARAP, Ly83, PLOSL, TYROBP, tyrpbpProtein level used designations for TYROBP
- TYRO protein tyrosine kinase-binding protein
- TYRO protein tyrosine kinase binding protein
- DAP12 protein
- dap12
- DAP12
- DNAX-activation protein 12
- killer cell activating receptor-associated protein
- KAR-associated protein
- killer activating receptor associated protein
- killer-activating receptor-associated protein
- killer cell activating receptor associated protein
- immunoreceptor DAP12
- tyrosine kinase binding protein
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