WWP1 Produits
(WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))
Catégories
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
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Catégories WWP1 en vedette
WWP1 Anticorps
High quality antibodies with extensive validation data.
WWP1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
WWP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IP, IF, IHC (p)
Validations
- (6)
- (6)
N° du produit
ABIN564794
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN7245725
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN524448
Quantité
100 μg
Fiche technique
Fiche technique
WWP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6208453
Quantité
96 tests
Fiche technique
Fiche technique
WWP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125747
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325405
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3096355
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits WWP1
: "β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin." dans: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1864, Issue 6 Pt A, pp. 2199-2213, (2018) (PubMed).: "Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis." dans: Journal of molecular and cellular cardiology, Vol. 88, pp. 1-13, (2015) (PubMed).
: "MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 1, pp. 414-22, (2015) (PubMed).
: "Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53." dans: Biochemical and biophysical research communications, Vol. 448, Issue 3, pp. 248-54, (2014) (PubMed).
: "WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels." dans: Molecular and cellular biology, Vol. 34, Issue 19, pp. 3754-64, (2014) (PubMed).
: "The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis." dans: Bone, Vol. 50, Issue 4, pp. 813-23, (2012) (PubMed).
: "WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts." dans: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33447-56, (2011) (PubMed).
: "The E3 ubiquitin ligase WWP1 regulates ?Np63-dependent transcription through Lys63 linkages." dans: Biochemical and biophysical research communications, Vol. 402, Issue 2, pp. 425-30, (2010) (PubMed).
: "Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5." dans: The Biochemical journal, Vol. 423, Issue 1, pp. 31-9, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à WWP1
WW domain containing E3 ubiquitin protein ligase 1 (WWP1), WW domain containing E3 ubiquitin protein ligase 1 (Wwp1), WW domain containing E3 ubiquitin protein ligase 1 (wwp1), 8030445B08Rik, AIP5, aip5, hSDRP1, hsdrp1, SDRP1, Tiul1, tiul1, WWP1Protein level used designations for WWP1
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Nedd-4-like ubiquitin-protein ligase
- TGIF-interacting ubiquitin ligase 1
- WW domain-containing protein 1
- atrophin-1 interacting protein 5
- atrophin-1-interacting protein 5
- WW domain containing E3 ubiquitin protein ligase 1
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