CD45 anticorps (PerCP)
(7 références)Aperçu rapide pour CD45 anticorps (PerCP) (ABIN302052)
Antigène
Voir toutes CD45 (PTPRC) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Fonction
- Anti-Hu CD45 PerCP
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Aucune reactivité croisée
- Cheval
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Réactivité croisée (Details)
- Human
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Attributs du produit
- The antibody MEM-28 reacts with an extracellular epitope on all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
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Purification
- Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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Immunogène
- Human thymocytes and T lymphocytes.
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Isotype
- IgG1
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anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody
PTPRC Reactivité: Humain FACS, IHC, WB, IF Hôte: Souris Monoclonal 2B11-PD7-26 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 371-556) antibodyPTPRC Reactivité: Souris IHC, WB, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 193-575) antibodyPTPRC Reactivité: Humain IHC, WB, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC Reactivité: Humain FACS, IHC, WB, IF Hôte: Lapin Monoclonal PTPRC-2877R unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (C-Term) antibodyPTPRC Reactivité: Humain FACS, IHC, WB, IP, ICC, IF (p) Hôte: Lapin Monoclonal BL-178-12C7 unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 24-575) antibodyPTPRC Reactivité: Humain FACS, IHC, WB, IF, ELISA Hôte: Souris Monoclonal 17H9D4 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (C-Term) antibodyPTPRC Reactivité: Humain, Souris, Rat, Chien, Poulet, Boeuf (Vache), Cat, Lapin, Mouton, Cobaye, Porc, Chévre, Singe, Cheval, Avian, Âne, Hamster WB, IHC (p), IHC (fro) Hôte: Chèvre Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 928-989) antibodyPTPRC Reactivité: Humain IHC, ELISA Hôte: Souris Monoclonal 5D3A3 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 431-577) antibodyPTPRC Reactivité: Humain FACS, IHC, ELISA Hôte: Souris Monoclonal 1B9B10 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 378-577) antibodyPTPRC Reactivité: Humain, Souris, Rat FACS, IHC, WB, ELISA, ICC Hôte: Souris Monoclonal 2H3E2 unconjugated
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Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Do not freeze,Protect from prolonged exposure to light
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Stock
- 4 °C
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Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142953, (2015) (PubMed).
: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." dans: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).
: "Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency." dans: Gene, Vol. 498, Issue 2, pp. 183-95, (2012) (PubMed).
: "Pivotal advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation." dans: Journal of leukocyte biology, Vol. 90, Issue 1, pp. 5-19, (2011) (PubMed).
: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." dans: International immunology, Vol. 19, Issue 5, pp. 675-84, (2007) (PubMed).
: "Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules." dans: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7955-61, (2002) (PubMed).
: "CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes." dans: Blood, Vol. 91, Issue 10, pp. 3901-8, (1998) (PubMed).
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- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
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Autre désignation
- CD45
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Sujet
- Protein tyrosine phosphatase receptor type C,CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10 % of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.,LCA, T200, LY5, B220, GP180, TPC
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ID gène
- 5788
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UniProt
- P08575
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Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
Antigène
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