GLUT4 anticorps
Aperçu rapide pour GLUT4 anticorps (ABIN218433)
Antigène
Voir toutes GLUT4 (SLC2A4) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- Recognizes human Solute carrier family 2, facilitated glucose transporter member 4, also known as glucose transporter 4 or GLUT4. GLUT4 is a 509 amino acid ~50 kD multi-pass transmembrane protein located primarily in the perinuclear region and is translocated to the plasma membrane where it is rapidly reinternalized. Does not react with HEP G2 type glucose transporter in human erythrocytes, rat brain or other tissues that do not exhibit sensitivity to insulin. GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
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Aucune reactivité croisée
- Porc
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Purification
- Affinity purified
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Immunogène
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A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to keyhole limpet hemocyanin.
Type of Immunogen: Synthetic peptide - KLH conjugated
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anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 224-353) antibody
SLC2A4 Reactivité: Humain, Souris WB, IHC, ELISA, ICC, FACS Hôte: Souris Monoclonal 3G10A3 unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 333-509) antibodySLC2A4 Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 401-509) antibodySLC2A4 Reactivité: Humain, Souris, Rat, Porc, Chévre, Mouton WB, ELISA, IHC (p), IHC (fro), FACS, IF (cc), IF (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 224-353) antibodySLC2A4 Reactivité: Humain, Souris WB, IHC, ELISA, FACS, IF/ICC Hôte: Souris Monoclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 223-287) antibodySLC2A4 Reactivité: Humain WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (N-Term) antibodySLC2A4 Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chévre, Cheval, Chien, Cobaye, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (N-Term) antibodySLC2A4 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 228-292) antibodySLC2A4 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibodyVerified SLC2A4 Reactivité: Humain, Souris WB, IHC, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (AA 467-509) antibodySLC2A4 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 2A4 unconjugated
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Indications d'application
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Approved: IHC, IHC-Fr, IHC-P (10 - 20 μg/mL), IP, WB
Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 10-20 μg/mL. -
Commentaires
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Target Species of Antibody: Human
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- PBS, 0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- GLUT4 (SLC2A4) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4))
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Autre désignation
- SLC2A4 / GLUT4 / GLUT-4
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Sujet
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Name/Gene ID: SLC2A4
Subfamily: Sugar transporter
Family: Transporter
Synonyms: SLC2A4, Glucose transporter 4, Glucose transporter GLUT4, GLUT4, GLUT-4 -
ID gène
- 6517
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UniProt
- P14672
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Pathways
- AMPK Signaling, Carbohydrate Homeostasis, Proton Transport, Brown Fat Cell Differentiation, L'effet Warburg
Antigène
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