CD45 anticorps (FITC)
Aperçu rapide pour CD45 anticorps (FITC) (ABIN118213)
Antigène
Voir toutes CD45 (PTPRC) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Specificité
- CD45R
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Purification
- Affinity Chromatography on Protein G
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Immunogène
- Mouse pre-B tumour cells (RAW112).
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Isotype
- IgG2a
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anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody
PTPRC Reactivité: Humain FACS, IHC, WB, IF Hôte: Souris Monoclonal 2B11-PD7-26 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 371-556) antibodyPTPRC Reactivité: Souris IHC, WB, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 193-575) antibodyPTPRC Reactivité: Humain IHC, WB, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 24-575) antibodyPTPRC Reactivité: Humain FACS, IHC, WB, IF, ELISA Hôte: Souris Monoclonal 17H9D4 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (C-Term) antibodyPTPRC Reactivité: Humain, Souris, Rat, Chien, Poulet, Boeuf (Vache), Cat, Lapin, Mouton, Cobaye, Porc, Chévre, Singe, Cheval, Avian, Âne, Hamster WB, IHC (p), IHC (fro) Hôte: Chèvre Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 928-989) antibodyPTPRC Reactivité: Humain IHC, ELISA Hôte: Souris Monoclonal 5D3A3 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 431-577) antibodyPTPRC Reactivité: Humain FACS, IHC, ELISA Hôte: Souris Monoclonal 1B9B10 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 378-577) antibodyPTPRC Reactivité: Humain, Souris, Rat FACS, IHC, WB, ELISA, ICC Hôte: Souris Monoclonal 2H3E2 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC Reactivité: Humain FACS, WB, IP, IHC (p), ICC Hôte: Souris Monoclonal MEM-28 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC Reactivité: Humain FACS, IHC, WB, IF Hôte: Lapin Monoclonal PTPRC-2877R unconjugated Recombinant Antibody
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Indications d'application
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Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells in 100 μL. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 0.1 mg/mL
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Buffer
- PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing. Should it contain a precipitate we recommend microcentrifugation before use.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
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Autre désignation
- CD45 / LCA
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Sujet
- CD45R is a member of the protein tyrosine phosphatase (PTP) family and a major cell surface glycoprotein. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45R represents a restricted form of the CD45 family which primarily recognizes only cells of B lineage from proB cell through mature B lymphocytes and, prior to the availability of anti CD19 MAbs, was commonly used as a pan B cell marker. It also reacts with certain activated T cells, as well as non MHC restricted lytically active lymphokine activated killer (LAK) cells. CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
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ID gène
- 10090
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UniProt
- P06800
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Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
Antigène
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