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ABI3 encodes a member of an adaptor protein family. De plus, nous expédions ABI3 Protéines (7) et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Polyclonal ABI3 Primary Antibody pour WB - ABIN1881513
Ichigotani, Yokozaki, Fukuda, Hamaguchi, Matsuda: Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. dans Cancer research 2002
Show all 2 Pubmed References
Data show that protein-altering changes are in PLCG2 (Montrer PLCG2 Anticorps), ABI3, and TREM2 (Montrer TREM2 Anticorps) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Result links ABI3 to the pathogenesis and progression of some cancers and suggests that ABI3 or its pathway might have interest as therapeutic target.
Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
NESH (Abi-3), like Abi-1 (Montrer ABI1 Anticorps) and Abi-2 (Montrer ABI2 Anticorps), is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (Montrer ABL1 Anticorps).
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1 (Montrer ABI1 Anticorps), which led to the formation of a NESH/Abi-3-based WAVE2 (Montrer WASF2 Anticorps) complex.
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.
ABI gene family member 3
, ABI gene family, member 3
, new molecule including SH3
, NESH protein