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ACVR2A encodes activin A type II receptor. De plus, nous expédions Activin Receptor Type IIA Protéines (37) et Activin Receptor Type IIA Kits (15) et beaucoup plus de produits pour cette protéine.
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TGF-beta (Montrer TGFB1 Anticorps) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 (Montrer ZEB2 Anticorps) and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Data suggest ALK1 (Montrer ACVRL1 Anticorps) and ACVR2A/ACVR2B (Montrer ACVR2B Anticorps), acting as BMP9 (Montrer GDF2 Anticorps) co-receptors, rearrange pro-domains of BMP9 (Montrer GDF2 Anticorps)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
Activin A (Montrer INHBA Anticorps) inhibited signaling by BMP-6 (Montrer BMP6 Anticorps) and BMP-9 (Montrer GDF2 Anticorps) by competing for type 2 receptors ACVR2A and ACVR2B (Montrer ACVR2B Anticorps).
Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (Montrer INHBA Anticorps) (as seen in pre-eclampsia).
Adenomyotic tissues express high levels of myostatin (Montrer MSTN Anticorps), follistatin (Montrer FST Anticorps), and activin (Montrer Actbeta Anticorps) type II receptors.
The gene ACVR2A was associated with the more severe early onset preeclampsia.
For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
ACVR2A was identified as a subnetwork component in functional association network analysis.
ACVR2A showed statistically significant differential dose-expression relationship.
This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B (Montrer ACVR2B Anticorps) or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B (Montrer ACVR2B Anticorps)-deficient mice exhibit no significant change in any bone parameter.
miR (Montrer MLXIP Anticorps)-125b regulated the activin (Montrer Actbeta Anticorps)/Smad2 (Montrer SMAD2 Anticorps) signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a
Our study shows that a miR (Montrer MLXIP Anticorps)-590/Acvr2a/Rad51b (Montrer Rad51B Anticorps) signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Bmpr2 (Montrer BMPR2 Anticorps) and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1 (Montrer HAND1 Anticorps), Th2, and Treg.
stimulates expression of APRIL via the Smad3 (Montrer SMAD3 Anticorps) and ERK (Montrer EPHB2 Anticorps)/CREB (Montrer CREB1 Anticorps) pathways in macrophages
Results demonstrated that BMPRII (Montrer BMPR2 Anticorps) and ActRII are the functional type II TGF-beta (Montrer TGFB1 Anticorps) receptors in BMP-9 (Montrer GDF2 Anticorps)-induced osteogenic differentiation of C3H10T1/2 cells.
The coordinated activity of ActRIIA and BMPRII (Montrer BMPR2 Anticorps) receptor subunits selectively mediates the chemotactic response to BMP7 (Montrer BMP7 Anticorps).
Activin (Montrer Actbeta Anticorps) type IIB(ActRIIB (Montrer ACVR2B Anticorps)) and its subfamily receptor, Activin (Montrer Actbeta Anticorps) type IIA (ActRIIA), cooperatively mediate the Gdf11 (Montrer GDF11 Anticorps) signal in patterning the axial vertebrae
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
activin receptor IIA
, activin receptor type-2A
, activin A receptor, type IIA
, activin receptor type IIA
, type II activin receptor
, activin A receptor, type II
, activin receptor, type IIA
, activin receptor type II
, activin type 2 receptor
, activin receptor IIa