anticorps ACVR2, anticorps ACVR2A, anticorps XSTK9, anticorps actrii, anticorps acvr2, anticorps ACTRII, anticorps Acvr2, anticorps rActR-II, anticorps actr2a, anticorps acvr2a, anticorps wu:fa02e10, anticorps ActrIIa, anticorps TactrII, anticorps activin A receptor type 2A, anticorps activin A receptor type 2A L homeolog, anticorps activin A receptor type 2Aa, anticorps activin receptor IIA, anticorps ACVR2A, anticorps acvr2a, anticorps Acvr2a, anticorps acvr2a.L, anticorps acvr2aa
Sujet
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.