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CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. De plus, nous expédions CALHM1 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population
In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.
CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]
The rare R154H variant interferes with CALHM1 control of cytosolic Ca2 (Montrer CA2 Anticorps)+ and Abeta (Montrer APP Anticorps) accumulation.
CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.
This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population
rare genetic variants in CALHM1 lead to Ca(2 (Montrer CA2 Anticorps)+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass (Montrer ASS1 Anticorps) cascade.
The study identifies a previously uncharacterized mechanism of control of Ca(2 (Montrer CA2 Anticorps)+)-dependent ERK1/2 (Montrer MAPK1/3 Anticorps) signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.
CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception
Thus, CALHM1 controls synaptic activity in cerebral neurons and is required for the flexible processing of memory in mice.
Abeta (Montrer APP Anticorps) level reduction by CALHM1 could be explained by an increase in extracellular Abeta (Montrer APP Anticorps) degradation by insulin-degrading enzyme (Montrer IDE Anticorps).
Multiple transduction pathways make complex, concentration-dependent contributions to salty taste perception. One of these pathways depends on CALHM1 to detect hypertonic NaCl in the mouth and signal the aversive taste of concentrated salt.
This study demonistrated that the Calhm1 knockot mice consumed only half as much sugar per day as did Wild type mice.
Calhm1 was of rare abundance in brain tissues
CALHM1 is an evolutionarily conserved ion channel family that detects membrane voltage and extracellular Ca(2 (Montrer CA2 Anticorps)+) levels and plays a role in cortical neuronal excitability and Ca(2 (Montrer CA2 Anticorps)+) homeostasis
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.
calcium homeostasis modulator 1
, novel protein similar to vertebrate calcium homeostasis modulator protein family
, calcium homeostasis modulator protein 1
, family with sequence similarity 26, member C