Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. De plus, nous expédions CENPT Anticorps (27) et CENPT Protéines (5) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 15 products:
These results support the existence of 2 pathways for kinetochore assembly directed by CENP-C (Montrer CENPC1 Kits ELISA) and CENP-T/W, which can be reconstituted in Xenopus egg extracts.
Whereas CENP-C (Montrer CENPC1 Kits ELISA) recruits a single MIS12 (Montrer MIS12 Kits ELISA):NDC80 (Montrer NDC80 Kits ELISA) complex, the authors show here that CENP-T binds one MIS12 (Montrer MIS12 Kits ELISA):NDC80 (Montrer NDC80 Kits ELISA) and two NDC80 (Montrer NDC80 Kits ELISA) complexes upon phosphorylation by the mitotic CDK1 (Montrer CDK1 Kits ELISA):Cyclin B complex at three distinct CENP-T sites.
FACT chaperone stabilizes the soluble CENP-T/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T/-W deposition at centromeres.
We used a synthetic system to dissect how CenH3(CENP-A (Montrer CENPA Kits ELISA)) contributes to the accumulation of CENP-C (Montrer CENPC1 Kits ELISA) and CENP-T, two key components that are necessary for the formation of functional kinetochores
CENP-T directly interacts with Ndc80 (Montrer NDC80 Kits ELISA), which in turn promotes KNL1 (Montrer CASC5 Kits ELISA)/Mis12 (Montrer MIS12 Kits ELISA) complex recruitment at kinetochores during chromosome segregation.
CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator.
CENP-T provides a structural platform for outer kinetochore assembly.
results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 (Montrer NDC80 Kits ELISA) complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics
The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations.
Study demonstrates that CENP-W (Montrer CENPW Kits ELISA) forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3 (Montrer HIST3H3 Kits ELISA), but not with CENP-A (Montrer CENPA Kits ELISA), in centromeric regions.
CENP-T exchange into centromeres is restricted to the S-phase of the cell cycle as revealed by FRAP (Montrer FRAP1 Kits ELISA), suggesting a coreplicational loading mechanism.
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006
centromere protein T
, centromere protein T-like
, interphase centromere complex protein 22