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The protein encoded by DNAJB8 belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. De plus, nous expédions DNAJB8 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal DNAJB8 Primary Antibody pour EIA, WB - ABIN951945
Hageman, Rujano, van Waarde, Kakkar, Dirks, Govorukhina, Oosterveld-Hut, Lubsen, Kampinga: A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. dans Molecular cell 2010
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Taken together, the results indicate that DNAJB8 is expressed and has role in CRC (Montrer CALR Anticorps) CSC/CIC (Montrer CIC Anticorps) and that DNAJB8 is a novel target of CRC (Montrer CALR Anticorps) CSC/CIC (Montrer CIC Anticorps)-targeting immunotherapy.
The mechanism of DNAJB6 (Montrer DNAJB6 Anticorps) and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract.
Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma
DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins.
Dnajb8 has a role in tumor initiation, side population ratio and sphere formation but it is dispensable for stress responses
findings suggest that DNAJB8 plays a role in Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma (Montrer MOK Anticorps)
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.
dnaJ homolog subfamily B member 8
, DnaJ homolog 6