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The protein encoded by DUSP2 is a member of the dual specificity protein phosphatase subfamily. De plus, nous expédions DUSP2 Kits (2) et et beaucoup plus de produits pour cette protéine.
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Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer.
Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8 (Montrer IL8 Anticorps), which facilitates angiogenesis and tumour metastasis.
Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF (Montrer CTCF Anticorps) is involved in the epigenetic regulation of DUSP2 expression.
Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma.
Data show that hypoxia promotes lapatinib resistance in ERBB2 (Montrer ERBB2 Anticorps)-positive breast cancer cells through activation of the MEK (Montrer MAP2K1 Anticorps)-ERK (Montrer EPHB2 Anticorps) pathway a HIF-1 (Montrer HIF1A Anticorps)-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2).
DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis.
Dipyridamole reduced expression of PAC-1 (Montrer ADCYAP1R1 Anticorps) and CD62p (Montrer SELP Anticorps) in patients with malignant lymphoma.
DUSP2 is a key downstream regulator of HIF-1 (Montrer HIF1A Anticorps)-mediated tumor progression and chemoresistance
During apoptosis, p53 (Montrer TP53 Anticorps) activates transcription of PAC1 (Montrer ADCYAP1R1 Anticorps) by binding to a palindromic site in the PAC1 (Montrer ADCYAP1R1 Anticorps) promoter
relationships between the expression levels of CD61 (Montrer ITGB3 Anticorps), CD63 (Montrer CD63 Anticorps), and PAC-1 (Montrer ADCYAP1R1 Anticorps) on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation
Data indicate that dual specificity phosphatase 2 protein (DUSP2) is a true STAT3 (Montrer STAT3 Anticorps) transcription factor phosphatase that modulates the development of TH17 cells in the autoimmune response and inflammation.
DUSP2 plays no role in regulating obesity-associated inflammation and only a minor role in controlling insulin (Montrer INS Anticorps) sensitivity following high-fat diet in female, but not male, mice.
the expression of PAC1 in the thymus changes in reverse ratio with thymus index and in direct ratio with cell apoptosis and only low dose of PACAP had positive effects against the CPS-induced thymus atrophy.
Arg294 and Arg295 play an important role in PAC-1 (Montrer ADCYAP1R1 Anticorps) catalytic activation induced by ERK2 (Montrer MAPK1 Anticorps) binding
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
dual specificity protein phosphatase 2
, dual specificity protein phosphatase PAC-1
, dual-specificity phosphatase 2
, serine/threonine specific protein phosphatase