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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. De plus, nous expédions FBXL19 Anticorps (24) et FBXL19 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 (Montrer RAC3 Kits ELISA) by regulating its stability and regulates the TGFbeta1 (Montrer TGFB1 Kits ELISA)-induced E-cadherin (Montrer CDH1 Kits ELISA) down-regulation.
The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination.
SCF (Montrer KITLG Kits ELISA)(FBXL19) targets RhoA (Montrer RHOA Kits ELISA) for its disposal, a process regulated by Erk2 (Montrer MAPK1 Kits ELISA).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (Montrer IL33 Kits ELISA)-mediated activity by removing ST2L (Montrer TMED1 Kits ELISA), but not sST2 (Montrer SSTR2 Kits ELISA) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like
, jumonji C domain-containing histone demethylase 1C