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KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. De plus, nous expédions K(lysine) Acetyltransferase 2A Protéines (12) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal KAT2A Primary Antibody pour EIA, WB - ABIN356619
Kikuchi, Takami, Nakayama: GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. dans Gene 2005
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Human Polyclonal KAT2A Primary Antibody pour EIA, FACS - ABIN952987
Kelly, Lerin, Haas, Gygi, Puigserver: GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. dans The Journal of biological chemistry 2009
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Human Polyclonal KAT2A Primary Antibody pour EIA, WB - ABIN952986
Mao, Gluck, Li, Maine, Li, Zaidi, Repaka, Mayo, Burstein: GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. dans Genes & development 2009
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Human Monoclonal KAT2A Primary Antibody pour EIA, IF - ABIN487348
Wiper-Bergeron, Salem, Tomlinson, Wu, Haché: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. dans Proceedings of the National Academy of Sciences of the United States of America 2007
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Human Polyclonal KAT2A Primary Antibody pour WB - ABIN387930
Oishi, Kitagawa, Wada, Takezawa, Tora, Kouzu-Fujita, Takada, Yano, Yanagisawa, Kato: An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. dans The Journal of biological chemistry 2006
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Human Polyclonal KAT2A Primary Antibody pour ELISA, WB - ABIN1534045
Yang, Ogryzko, Nishikawa, Howard, Nakatani: A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. dans Nature 1996
Data suggest that expression of GCN5 (histone acetyltransferase GCN5) is induced in skeletal muscle during a 48-hour fast; in contrast, expression of SIRT1 (sirtuin 1 (Montrer SIRT1 Anticorps)) remains unchanged.
Orc5 (Montrer ORC5 Anticorps) associates with the H3 histone (Montrer HIST1H3B Anticorps) acetyl transferase (Montrer HAT1 Anticorps) GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5 (Montrer ORC5 Anticorps).
Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.
these results may point to the GCN5-NF-kappaB (Montrer NFKB1 Anticorps) pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.
Acetyltransferase p300 (Montrer EP300 Anticorps) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4 (Montrer CHD4 Anticorps)) to facilitate DNA double-strand break repair
Suggest lysine acetyltransfer as a potential regulator of platelet actin dynamics, and potential roles for lysine acetylation in the molecular coordination of platelet activation and function.
Data uncover GCN5 as a negative regulator of C/EBPalpha (Montrer CEBPA Anticorps) and demonstrate the importance of C/EBPalpha (Montrer CEBPA Anticorps) acetylation in myeloid differentiation.
GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 (Montrer STAT3 Anticorps) and AKT (Montrer AKT1 Anticorps) Signaling Pathways
results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a (Montrer TADA2A Anticorps)- or ADA2b (Montrer TADA2B Anticorps)-containing HAT (Montrer MGEA5 Anticorps) modules and is further increased by incorporation of the distinct HAT (Montrer MGEA5 Anticorps) modules in the ATAC (Montrer XCL1 Anticorps) or SAGA holo-complexes
GCN5 plays a positive role in human colon cancer development, and its suppression holds a great therapeutic potential in antitumor therapy
In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB (Montrer NFKB1 Anticorps) with IkappaBalpha (Montrer NFKBIA Anticorps)-SR or by GCN5 knockdown in these muscles also enhanced AKT (Montrer AKT1 Anticorps) and mechanistic target of rapamycin (mTOR (Montrer FRAP1 Anticorps)) activities, which also contributed to the reduction in atrophy.
Gcn5 and PCAF (Montrer KAT2B Anticorps) repress IFN-beta (Montrer IFNB1 Anticorps) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (Montrer TBK1 Anticorps) in the cytoplasm.
GCN5 and HDAC1 (Montrer HDAC1 Anticorps) are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 (Montrer HDAC1 Anticorps) during embryo development
In conclusion, these data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation.
Study reveals that Gcn5/PCAF (Montrer KAT2B Anticorps) facilitate adipogenesis through regulation of PPARgamma (Montrer PPARG Anticorps) expression and regulate brown adipogenesis by influencing Prdm16 (Montrer PRDM16 Anticorps) expression.
Sirt6 interacts with and modifies GCN5, enhancing GCN5's activity.
Data support a model in which p23 and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes.
Data have defined an important role for GCN5 in NSC and provided evidence that GCN5 is an important Myc (Montrer MYC Anticorps) transcriptional cofactor in vivo.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009
histone acetyltransferase KAT2A
, general control of amino acid synthesis 5-like 2
, GCN5 general control of amino-acid synthesis 5-like 2
, general control of amino acid synthesis protein 5-like 2
, K(lysine) acetyltransferase 2A
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
, General control of amino acid synthesis, yeast, homolog-like 2
, histone acetyltransferase GCN5
, lysine acetyltransferase 2A
, GCN5 general control of amino acid synthesis-like 2
, general control of amino acid synthesis, yeast homolog-like 2
, general control of amino acid synthesis-like 2