anti-Mycn (MYCN) Anticorps

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. De plus, nous expédions MYCN Protéines (7) et MYCN Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top anti-MYCN Anticorps sur anticorps-enligne.fr

Showing 10 out of 98 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB 100 μL Connectez-vous pour afficher 3 to 7 Days
$318.45
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Souris Inconjugué ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$444.19
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$493.17
Détails
Humain Lapin Inconjugué ELISA, WB The n-Myc Antibody is used in Western blot to detect Myc in human fetal kidney lysate. 0.1 mg Connectez-vous pour afficher 2 to 6 Days
$327.00
Détails
Humain Souris Inconjugué WB Western Blot analysis of MYCN expression in transfected 293T cell line by MYCN monoclonal antibody (M01), clone 3H4. Lane 1: MYCN transfected lysate(49.6 KDa). Lane 2: Non-transfected lysate. Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi used as specificity and loading control. 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$450.00
Détails
Humain Souris Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$537.17
Détails

MYCN Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-MYCN Anticorps mieux référencés

  1. Human Monoclonal MYCN Primary Antibody pour ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. dans The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody pour ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. dans Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody pour IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. dans Oncotarget 2016 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody pour WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. dans Molecular cancer research : MCR 2015 (PubMed)

Plus d’anticorps contre MYCN partenaires d’interaction

Human Mycn (MYCN) interaction partners

  1. data extend knowledge on roles of MCPIP1 (Montrer ZC3H12A Anticorps) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) pathway.

  2. Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.

  3. Common genetic variation predisposes to different neuroblastoma (Montrer ARHGEF16 Anticorps) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  4. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (Montrer RB1 Anticorps) gene.

  5. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (Montrer ARHGEF16 Anticorps), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (Montrer ARHGEF16 Anticorps).

  6. Many prognostic signatures for neuroblastoma (Montrer ARHGEF16 Anticorps) are confounded by MYCN amplification.

  7. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  8. miR (Montrer MLXIP Anticorps)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (Montrer CADM1 Anticorps), and an inverse correlation between miR (Montrer MLXIP Anticorps)-21 and CADM1 (Montrer CADM1 Anticorps) expression in vivo. MiR (Montrer MLXIP Anticorps)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  9. LMO1 (Montrer LMO1 Anticorps) is an important oncogene (Montrer RAB1A Anticorps) that promotes neuroblastoma (Montrer ARHGEF16 Anticorps) initiation, progression, and widespread metastatic dissemination.

  10. our results identify DOT1L (Montrer DOT1L Anticorps) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (Montrer ARHGEF16 Anticorps) oncogenesis. Furthermore, they characterize DOT1L (Montrer DOT1L Anticorps) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (Montrer ARHGEF16 Anticorps).

Mouse (Murine) Mycn (MYCN) interaction partners

  1. interactions of NF-kappaB (Montrer NFKB1 Anticorps) and N-myc with GLT-1/EAAT2 (Montrer SLC1A2 Anticorps) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  2. beta-catenin (Montrer CTNNB1 Anticorps) cooperates with the transcription factor Myc (Montrer MYC Anticorps) to activate the progenitor renewal program.

  3. we report the isolation and propagation of neuroblastoma (Montrer ARHGEF16 Anticorps) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (Montrer ARHGEF16 Anticorps) with MYCN amplification

  4. miR (Montrer MLXIP Anticorps)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  5. the role of N-myc in mouse lens development, was examined.

  6. Using comparative genomic hybridization, authors found that NCC (Montrer SLC12A3 Anticorps)-derived NBL (Montrer NUMBL Anticorps) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (Montrer NUMBL Anticorps) including 17q gain, 2p gain and loss of 1p36.

  7. a Mycn target gene encoding the miR (Montrer MLXIP Anticorps) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  8. The findings reveal a PLK1 (Montrer PLK1 Anticorps)-Fbw7 (Montrer FBXW7 Anticorps)-Myc (Montrer MYC Anticorps) signaling circuit that underlies tumorigenesis and validate PLK1 (Montrer PLK1 Anticorps) inhibitors, alone or with Bcl2 (Montrer BCL2 Anticorps) antagonists, as potential effective therapeutics for MYC (Montrer MYC Anticorps)-overexpressing cancers.

  9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (Montrer MMRN1 Anticorps)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 (Montrer GAB2 Anticorps) overexpression activated the Shp2 (Montrer PTPN11 Anticorps)-Ras (Montrer RAB1A Anticorps)-Erk (Montrer MAPK1 Anticorps) pathway, enhanced neuroblastoma (Montrer ARHGEF16 Anticorps) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (Montrer NF1 Anticorps) loss leads to aberrant activation of RAS (Montrer RAB1A Anticorps) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (Montrer ARHGEF16 Anticorps) in nf1 (Montrer NF1 Anticorps)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (Montrer NF1 Anticorps) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN profil antigène

Profil protéine

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with anti-Mycn (MYCN) Anticorps

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) anticorps
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) anticorps
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) anticorps
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) anticorps
  • olfactory receptor 8S1 (LOC515887) anticorps
  • MYCN proto-oncogene, bHLH transcription factor (mycn) anticorps
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) anticorps
  • bHLHe37 anticorps
  • c-nmyc anticorps
  • fb57a02 anticorps
  • MODED anticorps
  • mycn anticorps
  • mycn-a anticorps
  • mycn-b anticorps
  • mycna anticorps
  • MYCNOT anticorps
  • N-myc anticorps
  • Nmuc1 anticorps
  • Nmyc anticorps
  • Nmyc-1 anticorps
  • nmyc1 anticorps
  • ODED anticorps
  • wu:fb57a02 anticorps
  • XN-myc anticorps
  • xN-myc1 anticorps
  • XNmyc anticorps
  • zgc:85706 anticorps

Protein level used designations for anti-Mycn (MYCN) Anticorps

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
Fournisseurs de qualité sélectionnés pour anti-MYCN (MYCN) Anticorps
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