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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. De plus, nous expédions MYCN Protéines (7) et MYCN Kits (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 98 products:
Human Monoclonal MYCN Primary Antibody pour ChIP, CyTOF - ABIN152254
Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. dans The Journal of biological chemistry 2011
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Mouse (Murine) Polyclonal MYCN Primary Antibody pour ICC, IF - ABIN256650
Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. dans Developmental cell 2005
Show all 2 Pubmed References
Human Polyclonal MYCN Primary Antibody pour IF (p), IHC (p) - ABIN760676
Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. dans Oncotarget 2016
Human Polyclonal MYCN Primary Antibody pour WB - ABIN391590
Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. dans Molecular cancer research : MCR 2015
data extend knowledge on roles of MCPIP1 (Montrer ZC3H12A Anticorps) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) pathway.
Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.
Common genetic variation predisposes to different neuroblastoma (Montrer ARHGEF16 Anticorps) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]
Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (Montrer RB1 Anticorps) gene.
The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (Montrer ARHGEF16 Anticorps), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (Montrer ARHGEF16 Anticorps).
Many prognostic signatures for neuroblastoma (Montrer ARHGEF16 Anticorps) are confounded by MYCN amplification.
Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.
miR (Montrer MLXIP Anticorps)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (Montrer CADM1 Anticorps), and an inverse correlation between miR (Montrer MLXIP Anticorps)-21 and CADM1 (Montrer CADM1 Anticorps) expression in vivo. MiR (Montrer MLXIP Anticorps)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
LMO1 (Montrer LMO1 Anticorps) is an important oncogene (Montrer RAB1A Anticorps) that promotes neuroblastoma (Montrer ARHGEF16 Anticorps) initiation, progression, and widespread metastatic dissemination.
our results identify DOT1L (Montrer DOT1L Anticorps) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (Montrer ARHGEF16 Anticorps) oncogenesis. Furthermore, they characterize DOT1L (Montrer DOT1L Anticorps) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (Montrer ARHGEF16 Anticorps).
interactions of NF-kappaB (Montrer NFKB1 Anticorps) and N-myc with GLT-1/EAAT2 (Montrer SLC1A2 Anticorps) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.
beta-catenin (Montrer CTNNB1 Anticorps) cooperates with the transcription factor Myc (Montrer MYC Anticorps) to activate the progenitor renewal program.
we report the isolation and propagation of neuroblastoma (Montrer ARHGEF16 Anticorps) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (Montrer ARHGEF16 Anticorps) with MYCN amplification
miR (Montrer MLXIP Anticorps)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.
the role of N-myc in mouse lens development, was examined.
Using comparative genomic hybridization, authors found that NCC (Montrer SLC12A3 Anticorps)-derived NBL (Montrer NUMBL Anticorps) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (Montrer NUMBL Anticorps) including 17q gain, 2p gain and loss of 1p36.
a Mycn target gene encoding the miR (Montrer MLXIP Anticorps) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
The findings reveal a PLK1 (Montrer PLK1 Anticorps)-Fbw7 (Montrer FBXW7 Anticorps)-Myc (Montrer MYC Anticorps) signaling circuit that underlies tumorigenesis and validate PLK1 (Montrer PLK1 Anticorps) inhibitors, alone or with Bcl2 (Montrer BCL2 Anticorps) antagonists, as potential effective therapeutics for MYC (Montrer MYC Anticorps)-overexpressing cancers.
ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (Montrer MMRN1 Anticorps)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
In MYCN transgenic fish, Gab2 (Montrer GAB2 Anticorps) overexpression activated the Shp2 (Montrer PTPN11 Anticorps)-Ras (Montrer RAB1A Anticorps)-Erk (Montrer MAPK1 Anticorps) pathway, enhanced neuroblastoma (Montrer ARHGEF16 Anticorps) induction, and increased tumor penetrance.
The authors demonstrate in zebrafish that nf1 (Montrer NF1 Anticorps) loss leads to aberrant activation of RAS (Montrer RAB1A Anticorps) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (Montrer ARHGEF16 Anticorps) in nf1 (Montrer NF1 Anticorps)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (Montrer NF1 Anticorps) mutant embryos.
At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, N-myc protein
, neuroblastoma myc-related oncogene 1
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc-like protein
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
, MYCN proto-oncogene, bHLH transcription factor S homeolog
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a