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The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. De plus, nous expédions MYLIP Protéines (12) et MYLIP Kits (1) et beaucoup plus de produits pour cette protéine.
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the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR (Montrer LDLR Anticorps)- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor (Montrer LDLR Anticorps)
The long noncoding RNA RP1 (Montrer STK19 Anticorps)-13D10.2 may contribute to LDL cholesterol levels in response to statins.
Specifically, loss of IDOL increases LDLR (Montrer LDLR Anticorps) distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients
Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR (Montrer LDLR Anticorps).
Identify USP2 (Montrer USP2 Anticorps) as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (Montrer LDLR Anticorps) by IDOL.
The study identified MARCH6 (Montrer MARCH6 Anticorps) as a negative regulator of SREBP2 (Montrer SREBF2 Anticorps)-mediated transcription and described an unexpected E3 circuit functionally linking MARCH6 (Montrer MARCH6 Anticorps) and IDOL to limit uptake of low-density lipoprotein via the LDLR (Montrer LDLR Anticorps) pathway.
IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.
study indicates that MYLIP p.N342S might be a pharmacogenetic marker for lipid-lowering therapy in patients with FH.
Liver-specific expression of dominant-active IDOL is associated with hypercholesterolemia and a marked elevation in atherosclerotic lesions in transgenic mice.
evidence for the existence of an LXR (Montrer NR1H3 Anticorps)-IDOL-mediated internalization pathway for the LDLR (Montrer LDLR Anticorps) that is distinct from that used for lipoprotein uptake
Suggest Idol as a gatekeeper of LDLR (Montrer LDLR Anticorps)-dependent ApoE (Montrer APOE Anticorps) and Abeta (Montrer APP Anticorps) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.
Estradiol-treatment led to impaired contractile function in male cardiomyocytes only, which was characterized by increased Mylip mRNA and protein levels, and decreased myosin regulatory light chain protein.
These data identify the IDOL-LDLR (Montrer LDLR Anticorps) interaction as an evolutionarily conserved mechanism for the regulation of lipid uptake and suggest that this interaction could potentially be exploited for the pharmacologic modulation of lipid metabolism.
Data show that NPC1 (Montrer NPC1 Anticorps) deficiency has a major impact on VLDL metabolism in Apoe (Montrer APOE Anticorps)(-/-) mice through modulation of hepatic LDL-R protein levels, and a modest one on Pcsk9 (Montrer PCSK9 Anticorps) and Idol induction.
Data show that the identification of VLDLR (Montrer VLDLR Anticorps) and ApoER2 (Montrer LRP8 Anticorps) as Idol(Mylip) targets suggests potential roles for this LXR (Montrer NR1H3 Anticorps)-inducible E3 ligase in the central nervous system in addition to lipid metabolism.
study shows the LXR (Montrer NR1H3 Anticorps)-Idol(Mylip)-LDLR (Montrer LDLR Anticorps) axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
E3 ubiquitin-protein ligase MYLIP-A
, myosin regulatory light chain-interacting protein A
, myosin regulatory light chain interacting protein
, e3 ubiquitin-protein ligase MYLIP-like
, E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor
, E3 ubiquitin-protein ligase MYLIP
, band 4.1 superfamily member BZF1
, cellular modulator of immune recognition (c-MIR)
, inducible degrader of the LDL-receptor
, myosin regulatory light chain-interacting protein