anti-Protein Kinase, CGMP-Dependent, Type I (PRKG1) Anticorps

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). De plus, nous expédions Protein Kinase, CGMP-Dependent, Type I Kits (24) et Protein Kinase, CGMP-Dependent, Type I Protéines (12) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PRKG1 54286  
PRKG1 5592 Q13976
PRKG1 19091 P0C605
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Top anti-Protein Kinase, CGMP-Dependent, Type I Anticorps sur anticorps-enligne.fr

Showing 10 out of 70 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB The anti-cGKI beta Pab (ABIN392536) is used in Western blot to detect cGKI beta in 293 cell lysate (Lane 1) and mouse small intestine tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$265.00
Détails
Humain Lapin Inconjugué WB WB Image Sample (30 ug of whole cell lysate) A: JC B: BCL-1 7.5% SDS PAGE antibody diluted at 1:10000 100 μL Connectez-vous pour afficher 1 to 2 Days
$358.60
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC (p), WB Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with PRKG1 antibody ABIN307178 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Connectez-vous pour afficher 7 to 9 Days
$451.00
Détails
Humain Lapin Inconjugué IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human endometrial cancer, using cGK1, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC 7.5% SDS PAGE antibody diluted at 1:2000 100 μL Connectez-vous pour afficher 1 to 2 Days
$358.60
Détails
Humain Souris Inconjugué EIA, IHC (p), WB 50 μg Connectez-vous pour afficher 6 to 8 Days
$412.50
Détails
Humain Souris Inconjugué IF, IHC (p), WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$493.17
Détails
Boeuf (Vache) Lapin Inconjugué WB 0.1 mg Connectez-vous pour afficher 6 to 8 Days
$368.50
Détails
Humain Souris Inconjugué IF, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKG1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKG1. Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-PRKG1 mouse monoclonal antibody. (ABIN2453517, Dilution 1:50) 100 μL Connectez-vous pour afficher 2 to 3 Days
$423.50
Détails

PRKG1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Protein Kinase, CGMP-Dependent, Type I Anticorps mieux référencés

  1. Human Polyclonal PRKG1 Primary Antibody pour IHC (p), WB - ABIN392536 : Orstavik, Natarajan, Taskén, Jahnsen, Sandberg: Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). dans Genomics 1997 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Protein Kinase, CGMP-Dependent, Type I partenaires d’interaction

Human Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. redox-mediated guidance required PKG1 and consequently, its deficiency in vivo resulted in defective repair and enhanced neuropathic pain after nerve injury. PKG1-dependent repair functions will outweigh its signaling functions in spinal nociceptive LTP (Montrer SCP2 Anticorps), so that inhibition of PKG1 is no option for neuropathic pain.

  2. Oxidant signaling underlies PKGIalpha modulation of Ca2 (Montrer CA2 Anticorps)+ sparks and BKCa (Montrer KCNMA1 Anticorps) in myogenically active arterioles

  3. These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II.

  4. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC (Montrer SGCB Anticorps) and PKG, resulting in an activated sGC (Montrer SGCB Anticorps)/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone.

  5. these data indicate PKG as an intermediary in EGFR (Montrer EGFR Anticorps)-mediated cell death, likely via apoptotic pathway.

  6. The heterozygous c.530G>A:p.Arg177Gln PRKG1 variant was associated with early-onset thoracic aortic aneurysm and dissection in a Spanish family.

  7. cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo (Montrer C9orf3 Anticorps), cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

  8. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  9. The C42-C42' disulfide bond dramatically stabilizes PRKG1.

  10. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase (Montrer CDK7 Anticorps), cyclic GMP (Montrer NT5C2 Anticorps)-dependent, type I (PRKG1) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP (Montrer NP Anticorps)) rs1049564 (P(Meta) = 1.24 x 10(-7)).

Cow (Bovine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. NADPH regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH redox.

  2. The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR (Montrer UTS2R Anticorps) of its mRNA.

  3. Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.

  4. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

  5. purified cGMP kinase signaling complex contained alpha-actin (Montrer ACTA2 Anticorps), calponin H1, and phospholamban (Montrer PLN Anticorps)

  6. studies suggest that cross-activation of PKA in response to iNOS expression by inflammatory mediators downregulates cGMP-dependent protein kinase expression in bovine aortic vascular smooth muscle cells

  7. Demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 (Montrer PAK1 Anticorps) pathway is activated.

  8. cGMP-dependent protein kinase expression is regulated by soluble guanylyl cyclase in vascular smooth muscle cells

  9. cGMP-dependent protein kinase (Montrer CDK7 Anticorps) Ibeta binds to TFII-I (Montrer GTF2I Anticorps) and IRAG (Montrer MRVI1 Anticorps) through a common interaction motif

  10. cGMP binding destabilizes the N-terminus of cGMP-dependent protein kinase I alpha isozyme at the hinge region, centered around residue 77, while the C-terminus is protected from degradation.

Mouse (Murine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. analysis of the role of binding interface with protein kinase G-Ialpha leucine zipper in vascular function

  2. Brown adipose tissue, via Nox4-derived hydrogen peroxide, induces cyclic GMP-dependent protein kinase G type-1alpha activation, resulting in reduced vascular contractility.

  3. disulfide formation at Cys (Montrer DNAJC5 Anticorps)(43) does not directly activate PKGIalpha, and the C43S-mutant PKGIalpha has a higher Ka for cGMP. Results highlight that mutant enzymes should be carefully biochemically characterized before making in vivo inferences.

  4. PKG Ialpha disulfide formation triggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological therapies that elevate cGMP, which binds kinase to limit its oxidation.

  5. Cyclic GMP kinase (Montrer GUK1 Anticorps) deletion causes iron deficiency anemia, duodenal ulcers, and bleeding in the knockout mice.

  6. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  7. cGMP/protein kinase (Montrer CDK7 Anticorps) G signaling suppresses Itpr1 (Montrer ITPR1 Anticorps) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3 (Montrer CNGA3 Anticorps)-deficient mice.

  8. Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha (Montrer TNF Anticorps)-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42 (Montrer GKAP1 Anticorps)) and impairment of insulin (Montrer INS Anticorps) signals.

  9. miR (Montrer MLXIP Anticorps)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

  10. These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

Rabbit Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. The novel cGMP/PKG/ROS (Montrer ROS1 Anticorps)/calmodulin/CaMKII (Montrer CAMK2G Anticorps) signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.

Protein Kinase, CGMP-Dependent, Type I (PRKG1) profil antigène

Profil protéine

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Gene names and symbols associated with PRKG1

  • protein kinase, cGMP-dependent, type Ia (prkg1a) anticorps
  • protein kinase, cGMP-dependent, type I (PRKG1) anticorps
  • protein kinase, cGMP-dependent, type I (prkg1) anticorps
  • protein kinase, cGMP-dependent, type 1 (Prkg1) anticorps
  • protein kinase, cGMP-dependent, type I (Prkg1) anticorps
  • 1 anticorps
  • AW125416 anticorps
  • cGK anticorps
  • cGK 1 anticorps
  • cGK1 anticorps
  • CGKI anticorps
  • cGKI-alpha anticorps
  • cGKI-beta anticorps
  • Gm19690 anticorps
  • PKG anticorps
  • Pkgi anticorps
  • prkg1 anticorps
  • Prkg1b anticorps
  • Prkg1beta anticorps
  • Prkgr1b anticorps
  • zgc:63955 anticorps

Protein level used designations for PRKG1

cGMP-dependent protein kinase 1 , protein kinase, cGMP-dependent, type I , cGMP-dependent protein kinase 1, beta isozyme , cGMP-dependent protein kinase I alpha , cGK I alpha , cGMP-dependent protein kinase 1-like , cGMP dependent protein kinase type 1 , protein kinase, cGMP-dependent, regulatory, type I, beta , CGK 1 alpha , cGK 1 beta , cGK1 , cGKI-alpha , cGMP-dependent protein kinase 1, alpha isozyme , cGMP-dependent protein kinase I , cGK 1 , PKG1 alpha , cGMP-dependent protein kinase type 1 alpha , cGMP-dependent protein kinase type I beta

GENE ID SPECIES
394005 Danio rerio
744467 Pan troglodytes
100049290 Oryzias latipes
100388016 Callithrix jacchus
54286 Rattus norvegicus
5592 Homo sapiens
282004 Bos taurus
19091 Mus musculus
100008694 Oryctolagus cuniculus
733640 Sus scrofa
423682 Gallus gallus
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