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SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. De plus, nous expédions Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Anticorps (97) et beaucoup plus de produits pour cette protéine.
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KAT7 (Montrer MYST2 Protéines)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.
Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (Montrer CBX5 Protéines) and gamma, and enhances HP1beta (Montrer CBX1 Protéines) levels.
we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1
These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (Montrer DEFA1 Protéines)/DNMT3A (Montrer DNMT3A Protéines) in DNA methylation (Montrer HELLS Protéines)-based epigenetic silencing
PHF2 (Montrer PHF1 Protéines) is likely to repress rDNA transcription by competing with PHF8 (Montrer PHF8 Protéines) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
High SUV39H1 expression is associated with hepatocellular carcinoma.
Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (Montrer BCL2 Protéines), pro-caspase-9 (Montrer CASP9 Protéines), pro-caspase-3 (Montrer CASP3 Protéines) and C-myc (Montrer MYC Protéines). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.
SUV39H1 expression was upregulated in glioma cell lines and in glioma tissues compared to normal brain, being positively correlated with grade and histological malignancy.
Short-chain fatty acids from periodontal pathogens suppress EZH2 (Montrer EZH2 Protéines), and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication.
Activation of p38alpha (Montrer MAPK14 Protéines) displaces KMT1A from MyoD (Montrer MYOD1 Protéines) to initiate myogenic gene expression upon induction of myoblasts differentiation.
Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (Montrer CBX5 Protéines) to the promoter of the ancestral Oct4 (Montrer POU5F1 Protéines) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.
Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.
Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
These findings indicate that Suv39h1 enhances AP-2alpha (Montrer TFAP2A Protéines)-mediated transcriptional repression of C/EBPalpha (Montrer CEBPA Protéines) in an epigenetic manner and further inhibits adipocyte differentiation.
A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.
Data indicate that loss of suv39h1 prevents Myc (Montrer MYC Protéines)-induced chromosomal instability.
Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (Montrer IL2 Protéines) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (Montrer IL2 Protéines) transcription.
SirT1 (Montrer SIRT1 Protéines) preserves heterochromatin structure: it modulates Suv39h1 protein levels in stress conditions by preventing MDM2 (Montrer MDM2 Protéines)-mediated polyubiquitination at K87.
novel role for microRNA in the epigenetic regulation of inflammatory genes in vascular smooth muscle cells of diabetic mice through downregulation of SUV39h1.
The identification of a histone H3 (Montrer HIST3H3 Protéines) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
These results suggest that Dnmt1 (Montrer DNMT1 Protéines) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (Montrer DNMT1 Protéines) and Suv39h1 help guide the terminal differentiation of particular tissues.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
histone-lysine N-methyltransferase SUV39H1
, su(var)3-9 homolog 1
, Su(var)3-9 homolog 1
, histone H3-K9 methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 1
, lysine N-methyltransferase 1A
, position-effect variegation 3-9 homolog
, H3-K9-HMTase 1
, Suv39h histone methyltransferase
, histone-lysine N-methyltransferase SUV39H1-A
, su(var)3-9 homolog 1-A
, suppressor of variegation 3-9 homolog 1
, suppressor of variegation 3-9 homolog 1-A
, suppressor of variegation 3-9-like 1a