TIMELESS Interacting Protein (TIPIN) Kits ELISA

Required for normal progression of S-phase. De plus, nous expédions TIPIN Anticorps (71) et TIPIN Protéines (10) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TIPIN 100359731  
TIPIN 54962 Q9BVW5
TIPIN 66131 Q91WA1
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Plus Kits ELISA pour TIPIN partenaires d'interaction

Xenopus laevis TIMELESS Interacting Protein (TIPIN) interaction partners

  1. Mta2 (Montrer MTA2 Kits ELISA) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  2. data indicate that Tipin/Tim1/And1 (Montrer WDHD1 Kits ELISA) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

Human TIMELESS Interacting Protein (TIPIN) interaction partners

  1. the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin.

  2. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.

  3. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (Montrer MERTK Kits ELISA) DNA ligand.

  4. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.

  5. We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.

  6. RPA (Montrer RPA1 Kits ELISA)-covered ssDNA not only supports recruitment and activation of ATR (Montrer ANTXR1 Kits ELISA) but also, through Tipin and Claspin (Montrer CLSPN Kits ELISA), it plays an important role in the action of ATR (Montrer ANTXR1 Kits ELISA) on its critical downstream target Chk1 (Montrer CHEK1 Kits ELISA)

  7. The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.

  8. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin (Montrer CLSPN Kits ELISA) in response to replication checkpoint

  9. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells

  10. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

Mouse (Murine) TIMELESS Interacting Protein (TIPIN) interaction partners

  1. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes

  2. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  3. The tim-Tipin dysfunction creates an indispensible reliance on the ATR (Montrer ATR Kits ELISA)-Chk1 (Montrer CHEK1 Kits ELISA) pathway for continued DNA synthesis.

TIPIN profil antigène

Antigen Summary

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

Gene names and symbols associated with TIPIN

  • timeless interacting protein (tipin) anticorps
  • TIMELESS interacting protein (TIPIN) anticorps
  • timeless interacting protein (LOC100359731) anticorps
  • timeless interacting protein (Tipin) anticorps
  • XTimeless interacting protein (xtipin) anticorps
  • 1110005A05Rik anticorps
  • 1110018P21Rik anticorps
  • MGC82649 anticorps
  • RGD1564084 anticorps
  • tipin anticorps
  • zgc:91928 anticorps

Protein level used designations for TIPIN

timeless interacting protein , TIMELESS interacting protein , timeless-interacting protein , TIMELESS-interacting protein , CSM3 homolog , mitotic phosphoprotein 67

GENE ID SPECIES
444047 Xenopus laevis
453525 Pan troglodytes
100126681 Xenopus (Silurana) tropicalis
100359731 Rattus norvegicus
445058 Danio rerio
415548 Gallus gallus
54962 Homo sapiens
100683743 Canis lupus familiaris
506176 Bos taurus
66131 Mus musculus
363076 Rattus norvegicus
394376 Xenopus laevis
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