TRKA anticorps (Middle Region)
(3 références)Aperçu rapide pour TRKA anticorps (Middle Region) (ABIN967209)
Antigène
Voir toutes TRKA (NTRK1) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- Middle Region
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Réactivité croisée
- Souris, Rat (Rattus)
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Réactivité croisée (Details)
- No cross reactivity with other proteins.
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Attributs du produit
- Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor ( NTRK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
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Immunogène
- A synthetic peptide corresponding to a sequence in the middle region of human NTRK1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
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Isotype
- IgG
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anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr681), (Tyr680) antibody
NTRK1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 725-821) antibodyNTRK1 Reactivité: Humain, Souris, Rat WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 769-796) antibodyNTRK1 Reactivité: Humain, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB16572 unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 342-356), (Extracellular) antibodyKO Validated NTRK1 Reactivité: Rat WB, IHC, IF, FACS, IC, LCI Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-208) antibodyNTRK1 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (C-Term) antibodyNTRK1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 769-796) antibodyNTRK1 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 Reactivité: Humain, Souris WB, ELISA, IF, FACS Hôte: Lapin Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 Reactivité: Humain, Souris WB, IF, FACS Hôte: Lapin Polyclonal RB17710 unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr496) antibodyNTRK1 Reactivité: Humain, Souris, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
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Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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Agent conservateur
- Sodium azide, Thimerosal (Merthiolate)
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- -20 °C
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Stockage commentaire
- At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
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: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, (2005) (PubMed).
: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." dans: Nature genetics, Vol. 13, Issue 4, pp. 485-8, (1996) (PubMed).
: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, (1996) (PubMed).
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- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
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Autre désignation
- High affinity nerve growth factor receptor (NTRK1)
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Sujet
- Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 (Neurotrophin-4) and BDNF, and NTF3 (Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA (NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform (s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect (s) of the nervous system.
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Pathways
- Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Antigène
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