Desmoglein 2 anticorps
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- Antigène Voir toutes Desmoglein 2 (DSG2) Anticorps
- Desmoglein 2 (DSG2)
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache)
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Desmoglein 2 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody recognizes Desmoglein 1+2 (desmosome-specific cadherins) in desmosome-bearing cells. It does not react with cells containing plaque-bearing junctions of non-desmosomal type. Tumors Specifically Detected: All epithelium-derived tumors, notably carcinomas, and meningiomas. Polypeptide Reacting: Mr 165000 Desmoglein, "band 3" polypeptide of the desmosomal complex. Epitope Recognized: Localized at the repeating unit domain ("RUD") of the cytoplasmic C-terminal part of the polypeptide. Reactivities on Cultured Cell Lines (tested so far): A-431, MCF-7, TR-146, PLC and various other Human epithelial cell lines, Bovine BMGE+H, BMGE-H, MDBK.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Bovine, Rat and Mouse.
- Purification
- Affinity Chromatography on Protein A
- Immunogène
- "Band 3" polypeptide of isolated desmosomes from Bovine muzzle epidermis
- Clone
- DG3-10
- Isotype
- IgG1
- Top Product
- Discover our top product DSG2 Anticorps primaire
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- Indications d'application
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Western blotting. Immunofluorescence Microscopy. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Embedded Tissue (after microwave treatment). Working Dilution: Dilute at least 1/10 with PBS, pH 7.4, for Immunohistochemicalapplication. Incubation time: 1 h at RT, extended with paraffin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore with 1.0 mL distilled water.
- Buffer
- Final Solution contains PBS, pH 7.4 with 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Desmoglein 2 (DSG2)
- Autre désignation
- Desmoglein-2 (DSG2 Produits)
- Synonymes
- anticorps DSG2, anticorps dsc, anticorps dsga, anticorps si:dkeyp-51f12.6, anticorps wu:fj23f02, anticorps ARVC10, anticorps ARVD10, anticorps CDHF5, anticorps CMD1BB, anticorps HDGC, anticorps AA408168, anticorps D18Ertd293e, anticorps desmoglein 2, anticorps desmoglein 2, tandem duplicate 1, anticorps DSG2, anticorps dsg2.1, anticorps dsg2, anticorps Dsg2
- Sujet
- Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 and 2 are calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18.Synonyms: CDHF4, CDHF5, DG1, DGI, DSG-1, DSG-2, DSG1, DSG2, Desmoglein1, Desmoglein2, Desmosomal glycoprotein 1, HDGC, Pemphigus foliaceus antigen
- ID gène
- 1829
- NCBI Accession
- NP_001934
- UniProt
- Q14126
- Pathways
- Cell-Cell Junction Organization
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