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Lamin A/C anticorps (LMNA)

Détail du produit anti-LMNA anticorps No. ABIN1580429, Fournisseur: Connectez-vous pour afficher
Antigène
  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • Dhe
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • lmna-A
  • lamin-L(III)-like
Alternatives
anti-Souris Lamin A/C anticorps pour Western Blotting
Reactivité
Humain, Boeuf (Vache), Porc, Souris, Rat (Rattus), Mammifères
294
146
130
30
25
14
11
10
8
5
4
4
3
2
1
1
1
1
1
1
Hôte
Souris
209
111
3
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Lamin A/C est non-conjugé
5
4
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
275
109
100
77
63
58
33
32
32
24
11
2
2
2
2
2
2
1
Fournisseur
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Clone 4C4
Isotype IgG1
Purification affinity purified antibody
Autre désignation Lamin A/C (LMNA Antibody Extrait)
Sujet Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm. Lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene, while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74 kDa while Lamin C is 65 kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of maturation promoting factor, the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of Lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging. The HGNC name for this protein is LMNA.
Domaine de recherche Cytoskeleton, Extracellular Matrix
Pathways Apoptose, Caspase Cascade in Apoptosis
Indications d'application The antibody solution can be used at dilutions of at least 1:1,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:10,000 or lower.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store at 4°C short term or -20°C long term.
Supplier Images
Western Blotting (WB) image for anti-Lamin A/C anticorps (LMNA) (ABIN1580429) Strip blots of crude HeLa cell extract stained with MCS-4C4. Note two strong clean ba...
Immunofluorescence (IF) image for anti-Lamin A/C anticorps (LMNA) (ABIN1580429) HeLa cells staining with ABIN1580429 (red), and counterstained with ’s chicken polycl...
Reference: Background Liu, Zhou: "Lamin A/C, laminopathies and premature ageing." dans: Histology and histopathology, Vol. 23, Issue 6, pp. 747-63, 2008 (PubMed).

Fisher, Chaudhary, Blobel: "cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 17, pp. 6450-4, 1986 (PubMed).