Formin Binding Protein 1 (FNBP1) anticorps (HRP)

Détails pour le produit réf. ABIN1712049, Fournisseur: Connectez-vous pour afficher
Antigène
  • MGC122623
  • MGC146466
  • FBP17
  • 1110057E06Rik
  • 2210010H06Rik
  • FBP1
  • Fbp17
  • formin binding protein 1
  • FNBP1
  • fnbp1
  • Fnbp1
Reactivité
Humain, Souris, Rat (Rattus)
59
32
32
7
5
5
4
2
2
2
1
1
1
1
1
Hôte
Lapin
40
20
Clonalité
Polyclonal
Conjugué
HRP
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
41
17
14
13
8
5
1
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human FBP17
Isotype IgG
Purification Purified by Protein A.
Autre désignation Fbp17 (FNBP1 Antibody Extrait)
Sujet

FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.

Synonyms: FBP1, FBP17, FNBP1, FNBP1_HUMAN, Formin binding protein 1, Formin binding protein 17, Formin-binding protein 1, Formin-binding protein 17, hFBP17, KIAA0554, MGC126804.

ID gène 23048
Domaine de recherche Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months