Anaphase Promoting Complex Subunit 11 (ANAPC11) anticorps (HRP)

Détails pour le produit réf. ABIN1712104, Fournisseur: Connectez-vous pour afficher
Antigène
  • anapc11
  • RGD1561880
  • DDBDRAFT_0187183
  • DDBDRAFT_0231277
  • DDB_0187183
  • DDB_0231277
  • zgc:153671
  • si:dkey-237i9.4
  • APC11
  • Apc11p
  • 1110011I19Rik
  • R75218
  • F10A16.17
  • F10A16_17
  • anaphase-promoting complex/cyclosome 11
  • anaphase promoting complex subunit 11
  • anaphase-promoting complex subunit 11-like
  • Apc11p
  • anaphase-promoting complex subunit Apc11
  • similar to S. cerevisiae APC11 (YDL008W) anaphase promoting complex subunit
  • ubiquitin-protein ligase Anaphase Promoting Complex
  • hypothetical protein
  • anaphase-promoting complex/cyclosome 11
  • APC11 anaphase promoting complex subunit 11 homolog (yeast)
  • anaphase-promoting complex subunit 11
  • anapc11
  • Anapc11
  • LOC615066
  • APC11
  • apc11
  • ANAPC11
  • LOC692923
Reactivité
Humain, Souris, Rat (Rattus)
109
28
27
16
3
1
Hôte
Lapin
60
41
9
Clonalité
Polyclonal
Conjugué
HRP
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
95
56
17
16
13
13
5
3
3
2
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human APC11
Isotype IgG
Purification Purified by Protein A.
Autre désignation Apc11 (ANAPC11 Antibody Extrait)
Sujet

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Synonyms: ANAPC 11, ANAPC11, Anaphase promoting complex subunit 11, Anaphase promoting complex subunit 11 homolog yeast, Anaphase promoting complex subunit 11 homolog, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p, APC11 anaphase promoting complex subunit 11 homolog yeast, APC11 anaphase promoting complex subunit 11 homolog, APC11, APC11_HUMAN, Apc11p, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, Hepatocellular carcinoma-associated RING finger protein, HSPC 214, HSPC214, MGC882, Yeast APC 11 homolog, Yeast APC11 homolog.

ID gène 51529
Domaine de recherche Coagulation
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months