GFM2 is a mitochondrial translation elongation factor. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.
Subcellular location: Mitochondrion
Synonyms: EF-G2mt, EFG2, EFG2mt, elongation factor G 2, mitochondrial, Elongation factor G2, G elongation factor mitochondrial 2, GFM2, hEFG2, mEFG 2, mEFG2, Mitochondrial elongation factor G2, mitochondrial ribosome recycling factor 2, MRRF2, MST027, MSTP027, OTTHUMP00000222951, OTTHUMP00000222952, ribosome-releasing factor 2, mitochondrial, RRF2, RRF2mt.