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KIT anticorps (Mast/stem Cell Growth Factor Receptor) (pTyr730) (HRP)

Détail du produit anti-KIT anticorps No. ABIN1712419, Fournisseur: Connectez-vous pour afficher
Antigène
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
  • kit oncogene
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Kit
  • KIT
Alternatives
anti-Humain KIT anticorps pour Immunofluorescence
Épitope
pTyr730
54
43
39
31
26
25
25
17
16
15
15
15
15
15
14
11
10
10
10
10
10
10
10
10
10
10
10
10
10
9
9
9
9
8
8
8
7
7
7
7
7
7
7
7
7
7
7
7
6
6
5
5
5
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
906
461
157
40
35
32
21
19
15
6
6
5
4
3
2
1
1
Hôte
Lapin
679
284
213
4
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp KIT est conjugé à/à la HRP
104
89
85
62
48
39
20
16
14
10
10
10
9
8
8
8
8
8
8
7
5
5
5
5
5
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
408
401
398
187
179
150
105
96
76
61
28
13
13
12
11
8
4
4
3
3
2
2
2
2
2
2
2
Options
Fournisseur
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Immunogène KLH conjugated synthetic phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr730
Isotype IgG
Purification Purified by Protein A.
Autre désignation C-Kit (KIT Antibody Extrait)
Sujet

c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.


Synonyms: c-Kit phospho Y730, c-Kit phospho Tyr730, p-c-Kit Tyr 730, C Kit, c-Kit, CD 117, CD117, CD117 antigen, KIT, KIT_HUMAN, Mast/stem cell growth factor receptor, Mast/stem cell growth factor receptor Kit, p145 c-kit, PBT, Piebald trait protein, Proto oncogene c Kit, Proto oncogene tyrosine protein kinase Kit, Proto-oncogene c-Kit, SCF Receptor, SCFR, soluble KIT variant 1, Stem cell factor receptor, tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.
ID gène 3815
Domaine de recherche Proliferation Markers
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months