Ethanolamine kinase 2, also known as EKI2, ETNK2 or HMFT1716, is a 386 amino acid protein that belongs to the choline/ethanolamine kinase family. Via the cytidine diphosphate (CDP) ethanolamine pathway, Ethanolamine kinase 2 catalyses the initial step of phosphatidylethanolamine (PtdEtn) biosynthesis. Ethanolamine kinase 2 is expressed in kidney, liver, testis, ovary and prostate, and is highly specific for ethanolamine phosphorylation. Upregulated during testis development, Ethanolamine kinase 2 may play an essential role in regulating placental hemostasis. Existing as three alternatively spliced isoforms, the gene encoding Ethanolamine kinase 2 maps to human and mouse chromosome 1. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8 % of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinsonâ€™s disease, Gaucher disease, schizophrenia and Usher syndrome.
Synonyms: 4933417N20Rik, AI197444, EC 220.127.116.11, EKI 2, EKI2, EKI2_HUMAN, Ethanolamine kinase 2, Ethanolamine kinase like protein, Ethanolamine kinase-like protein, ETNK 2, ETNK2, FLJ10761, HMFT1716, RP11 74C13.2, Tuc1.