PRKAA1 anticorps (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit) (pSer496) (HRP)

Details for Product anti-PRKAA1 Antibody No. ABIN1712622, Fournisseur: Connectez-vous pour afficher
Antigène
  • Prkaa1
  • ampk
  • ampka1
  • PRKAA1
  • AMPK
  • AMPKa1
  • AMPKalpha1
  • AI194361
  • AI450832
  • AL024255
  • C130083N04Rik
  • cb116
  • im:7154392
  • sb:cb130
  • wu:fa94c10
  • AMPK1
  • protein kinase, AMP-activated, alpha 3 catalytic subunit
  • protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Prkaa3
  • PRKAA1
  • prkaa1
  • Prkaa1
Alternatives
anti-Humain PRKAA1 anticorps pour Immunofluorescence (fixed cells)
Épitope
pSer496
30
22
18
16
16
14
13
10
8
5
5
5
4
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
300
195
185
28
19
17
10
9
9
8
6
5
5
4
3
3
2
2
1
1
Hôte
Lapin
251
65
1
Clonalité
Polyclonal
Conjugué
Cet anticorp PRKAA1 est conjugé à/à la HRP
12
11
11
8
7
7
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
260
115
103
93
70
38
29
26
21
5
4
3
2
2
1
Options
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Immunogène KLH conjugated synthetic phosphopeptide derived from mouse AMPK alpha 1 around the phosphorylation site of Ser496
Isotype IgG
Purification Purified by Protein A.
Autre désignation Ampk alpha 1 (PRKAA1 Antibody Extrait)
Sujet

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE, regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.

Synonyms: 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, Prkaa1

ID gène 105787
Domaine de recherche Cancer, Fatty Acids, Alzheimer's Disease
Pathways AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months