MTA2 anticorps (AA 652-668)
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- Antigène Voir toutes MTA2 Anticorps
- MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
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Épitope
- AA 652-668
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MTA2 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody reacts to MTA2 / PID. No cross response to MTA1.
- Purification
- Purified
- Immunogène
- Rabbit polyclonal PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID/MTA2 (6), which differ from the mouse sequence by one amino acid (7).
- Isotype
- IgG
- Top Product
- Discover our top product MTA2 Anticorps primaire
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- Indications d'application
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Western Blot: 0.5 to 1 μg/mL, a 75 kDa band can be detected. Tissue Expression: Widely expressed, located in the nucleus. Positive Control: HeLa cell lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- Phosphate buffered saline with 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Antigène
- MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
- Autre désignation
- MTA2 (MTA2 Produits)
- Synonymes
- anticorps MTA1L1, anticorps PID, anticorps fd61b05, anticorps wu:fd61b05, anticorps wu:fi29g02, anticorps zgc:63487, anticorps pid, anticorps mta1l1, anticorps MTA2, anticorps DKFZp470E0911, anticorps AW550797, anticorps Mata1l1, anticorps Mta1l1, anticorps mmta2, anticorps metastasis associated 1 family member 2, anticorps metastasis associated 1 family, member 2, anticorps metastasis-associated gene family, member 2, anticorps metastasis associated 1 family member 2 L homeolog, anticorps MTA2, anticorps mta2, anticorps Mta2, anticorps mta2.L
- Sujet
- The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6 - 8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex
- ID gène
- 9219
- NCBI Accession
- NP_004730
- UniProt
- O94776
- Pathways
- Chromatin Binding
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