CD14 anticorps (AA 9-13, AA 39-44)
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- Antigène Voir toutes CD14 Anticorps
- CD14
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Épitope
- AA 9-13, AA 39-44
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD14 est non-conjugé
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Application
- Flow Cytometry (FACS), Western Blotting (WB), ELISA, Agonist (Agon)
- Specificité
- Soluble and membrane bound human CD14. The antibody blocks LPS binding to membrane bound CD14
- Réactivité croisée
- Corynebacterium diphtheriae, Boeuf (Vache), Chien, Cheval, Porc
- Réactivité croisée (Details)
- CD14 of cattle++, swine ++, dog+ horse+
- Purification
- Protein G affinity column
- Immunogène
- Monocytes of different species and immunoaffinity purified soluble human CD14
- Clone
- BiG13
- Isotype
- IgG1
- Top Product
- Discover our top product CD14 Anticorps primaire
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- Indications d'application
- 20 μg/mL inhibits binding of 0.5 μg/ ml LPS to CD14.Binding titre at human CD14 transfected CHO-cells (FACS): more than 100.000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with bidistilled water
- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.5
- Agent conservateur
- Without preservative
- Stock
- -20 °C,-80 °C
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Differentiation and activation of equine monocyte-derived dendritic cells are not correlated with CD206 or CD83 expression." dans: Immunology, Vol. 139, Issue 4, pp. 472-83, (2013) (PubMed).
: "Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood." dans: Medical microbiology and immunology, Vol. 201, Issue 3, pp. 327-35, (2012) (PubMed).
: "Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6185-94, (2004) (PubMed).
: "Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis." dans: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 2, pp. 440-5, (2002) (PubMed).
: "Soluble CD14 in human breast milk and its role in innate immune responses." dans: Acta odontologica Scandinavica, Vol. 59, Issue 5, pp. 330-4, (2001) (PubMed).
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Differentiation and activation of equine monocyte-derived dendritic cells are not correlated with CD206 or CD83 expression." dans: Immunology, Vol. 139, Issue 4, pp. 472-83, (2013) (PubMed).
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- Antigène
- CD14
- Autre désignation
- CD14 (CD14 Produits)
- Synonymes
- anticorps CD14 molecule, anticorps CD14 antigen, anticorps CD14, anticorps Cd14
- Sujet
- Background: biG 13 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, weekly at surface of neutrophiles like Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 Molecule has been reported to be a receptor for endotoxin. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for LPS-LBP (lipopolysaccharide binding protein)-complexes.
- Poids moléculaire
- ~50kDa
- ID gène
- 929
- NCBI Accession
- NP_000582
- UniProt
- P08571
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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