TYK2 anticorps (pTyr1054)

N° du produit ABIN362143

Cet anticorps Lapin Polyclonal détecte spécifiquement TYK2 dans WB. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour TYK2 anticorps (pTyr1054) (ABIN362143)

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TYK2 anticorps

Épitope: pTyr1054

Specificité: The antibody detects endogenous level of TYK2 only when phosphorylated at tyrosine 1054.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: Peptide sequence around phosphorylation site of pTyr1054 (H-E-Y (p) -Y-R) derived from Human TYK2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur TYK2

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Autre désignation: TYK2

Sujet: TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin

Poids moléculaire: 140 kDa

NCBI Accession: NP_003322

UniProt: P29597

Pathways: Signalistation JAK/STAT, Hepatitis C